Ketosis slows the progression of PKD.

Ketosis slows the progression of PKD.
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酮症可减缓 PKD 的进展。

DOI:
10.1038/s41581-019-0226-4
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发表时间:
2020
期刊:
Nature reviews. Nephrology
影响因子:
--
通讯作者:
Carney,EllenF
Carney,EllenF
中科院分区:
--
文献类型:
--
作者:
Carney,EllenF

文献摘要

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New data from Thomas Weimbs and colleagues suggest that induction of ketosis inhibits the growth of renal cysts in autosomal dominant polycystic kidney disease (ADPKD).“We previously reported the surprising observation that a very mild reduction in food intake had a profound inhibitory effect on PKD progression in a mouse model,” says Weimbs.“At the same time, a group at the Mayo Clinic independently published very similar results but neither study identified how the intervention worked. Our subsequent research has focused on better understanding the underlying mechanisms.”