Removal of atrial natriuretic peptide by perfused rabbit lungs in situ.
Removal of atrial natriuretic peptide by perfused rabbit lungs in situ.
复制标题
通过原位灌注兔肺去除心钠素。
DOI：
10.1016/0006-291x(86)90715-1
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发表时间：
1986
影响因子：
3.1
通讯作者：
Gillis,CN
中科院分区：
文献类型：
--
作者：
Turrin,M;Gillis,CN
通过指示剂稀释方法测量兔肺对碘化 28-氨基酸心房钠尿肽 ([125I]ANP) 的去除情况。推注 6.5 pmol 的 [125I]ANP 后，单次通过肺部就去除了 66.9 ± 2.9%。激酶 II 抑制剂不会改变去除效果，但未标记的 ANP 可逆地降低去除效果。因此，肺可以通过不涉及激肽酶 II 水解的机制从肺循环中去除 ANP。因此，肺可能参与调节 ANP 的全身浓度，进而参与肾脏和其他作用。
Removal of iodinated 28-amino acid atrial natriuretic peptide ([125I]ANP) by rabbit lungs was measured by indicator-dilution methods. After bolus injection of 6.5 pmoles of [125I]ANP, 66.9 ± 2.9% was removed in a single pass through the lungs. Removal was unaltered by a kininase II inhibitor but was reversibly decreased by unlabelled ANP. Thus the lungs can remove ANP from the pulmonary circulation by a mechanism that does not involve hydrolysis by kininase II. Lungs therefore may be involved in regulating systemic concentrations and hence renal and other actions of ANP.