Methods and indicators to validate country reductions in incidence of hepatitis C virus infection to elimination levels set by WHO.
Methods and indicators to validate country reductions in incidence of hepatitis C virus infection to elimination levels set by WHO.
复制标题
DOI：
10.1016/s2468-1253(21)00311-3
复制
发表时间：
2022-04
影响因子：
35.7
通讯作者：
Vickerman, Peter
中科院分区：
文献类型：
--
作者：
Artenie, Adelina;Luhmann, Niklas;Lim, Aaron G.;Fraser, Hannah;Ward, Zoe;Stone, Jack;MacGregor, Louis;Walker, Josephine G.;Trickey, Adam;Marquez, Lara K.;Abu-Raddad, Laith J.;Ayoub, Houssein H.;Walsh, Nick;Hickman, Matthew;Martin, Natasha K.;Easterbrook, Philippa;Vickerman, Peter
《2016年全球卫生部门病毒性肝炎战略》的主要目标之一是到2030年消除作为公共卫生问题的丙型肝炎病毒，其定义为与2015年相比发病率降低80%，死亡率降低65%。尽管监测丙肝病毒发病率是验证丙肝病毒消除的关键，但各国使用金标准方法测量这一指标可能需要大量资源，这涉及对高危人群进行前瞻性丙肝病毒再检测。此外，很少有国家在2015年收集了高质量数据，证明到2030年将减少80%。在本文中，我们首先回顾了监测HCV发病率的不同方法，并讨论了它们的资源意义和对不同人群的适用性。其次，使用为各种全球环境开发的数学模型，我们评估HCV慢性或抗体流行趋势或HCV检测、治疗和预防性干预的扩大水平是否可以作为验证HCV发病率目标的可靠替代指标。第三，我们讨论了绝对HCV发病率目标的优缺点，并提出了一个合适的阈值。然后，我们根据现有的监测基础设施，提出了各国可用于验证HCV发病率目标的三种选择。
One of the main goals of the 2016 Global Health Sector Strategy on viral hepatitis is the elimination of hepatitis C virus (HCV) as a public health problem by 2030, defined as an 80% reduction in incidence and 65% reduction in mortality relative to 2015. Although monitoring HCV incidence is key to validating HCV elimination, it can be resource-intensive for countries to measure this metric using the gold-standard method, which involves prospective HCV re-testing of people at risk. Additionally, few countries have collected quality data in 2015 to document an 80% decrease by 2030. In this paper, we first review different methods by which HCV incidence can be monitored and discuss their resource implications and applicability to various populations. Second, using mathematical models developed for various global settings, we assess whether trends in HCV chronic or antibody prevalence or scale-up levels for HCV testing, treatment and preventative interventions can be used as reliable alternative indicators to validate the HCV incidence target. Third, we discuss the advantages and disadvantages of an absolute HCV incidence target and suggest a suitable threshold. We then propose three options that countries can use to validate the HCV incidence target, depending on the available surveillance infrastructure.
影响因子：
3.7
作者：
Sutton AJ;Gay NJ;Edmunds WJ;Hope VD;Gill ON;Hickman M
通讯作者：
Hickman M