Heme oxygenase-1 suppresses the apoptosis of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway
Heme oxygenase-1 suppresses the apoptosis of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway
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血红素加氧酶-1通过JNK/c-JUN信号通路抑制急性髓系白血病细胞凋亡
DOI：
10.1016/j.leukres.2015.02.009
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发表时间：
2015-05-01
影响因子：
2.7
通讯作者：
Wang, Jishi
中科院分区：
文献类型：
--
作者：
Lin, Xiaojing;Fang, Qin;Wang, Jishi
关于血红素加氧酶-1（HO-1）与急性髓系白血病（AML）之间相关性的研究较少。我们发现HO-1在大多数AML患者中异常过表达，特别是在急性单核细胞白血病（M5）和白细胞增多的患者中，并抑制HL-60和U937细胞的凋亡。此外，沉默 HO-1 可以延长异种移植小鼠模型的存活时间。进一步研究表明HO-1通过激活JNK/c-JUN信号通路抑制AML细胞的凋亡。这些数据表明 HO-1 在抑制细胞凋亡方面的分子作用，使其成为治疗 AML 的潜在靶点。 (C) 2015 Elsevier Ltd. 保留所有权利。
There are few studies on the correlation between heme oxygenase-1 (HO-1) and acute myeloid leukemia (AML). We found that HO-1 was aberrantly overexpressed in the majority of AML patients, especially in patients with acute monocytic leukemia (M5) and leukocytosis, and inhibited the apoptosis of HL-60 and U937 cells. Moreover, silencing HO-1 prolonged the survival of xenograft mouse models. Further studies demonstrated that HO-1 suppressed the apoptosis of AML cells through activating the JNK/c-JUN signaling pathway. These data indicate a molecular role of HO-1 in inhibiting cell apoptosis, allowing it to be a potential target for treating AML. (C) 2015 Elsevier Ltd. All rights reserved.