Immediate post-reminder injection of gamma-amino butyric acid (GABA) agonist midazolam attenuates reactivation of forgotten fear in the infant rat
Immediate post-reminder injection of gamma-amino butyric acid (GABA) agonist midazolam attenuates reactivation of forgotten fear in the infant rat
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DOI：
10.1037/0735-7044.121.6.1328
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发表时间：
2007-12-01
影响因子：
1.9
通讯作者：
Richardson, Rick
中科院分区：
文献类型：
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作者：
Kim, Jee Hyun;Richardson, Rick
J. H. Kim， G. McNally和R. Richardson（2006）报道，测试前注射一种GABA逆激动剂FG7142可以减轻大鼠的婴儿健忘症。由此推断，gaba能神经传递参与了发育大鼠的遗忘过程。目前的研究扩展了这一发现，通过检查GABA在幼鼠被遗忘的记忆的重新激活中的作用。16天大的老鼠习惯于害怕白噪音。在3天后的测试中，没有接受提醒治疗的大鼠表现出大量的遗忘。在测试前一天给予提醒性电击并注射生理盐水的大鼠中观察到记忆的重新激活（通过高水平冷冻来评估）。然而，给予提醒电击并立即注射咪达唑仑的大鼠未能表现出再激活效应。随后的实验重复了这一发现，并进一步表明，在提醒事件发生2小时后注射咪达唑仑并没有降低记忆再激活的效果。由此看来，gaba能神经传递的改变可能是幼鼠记忆再激活的一个潜在过程。
J. H. Kim, G. McNally, and R. Richardson (2006) reported that pretest injection of FG7142, a GABA inverse agonist, alleviated infantile amnesia in rats. From this, it was concluded that GABAergic neurotransmission is involved in the forgetting seen in the developing rat. The present study extends that finding by examining the role of GABA in the reactivation of a forgotten memory in the infant rat. Sixteen-day-old rats were conditioned to fear a white noise. When tested 3 days later, rats that had not received a reminder treatment exhibited substantial forgetting. Reactivation of memory (as assessed by high levels of freezing) was observed in rats that were given a reminder shock and injected with saline the day before test. However, rats given a reminder shock and injected with midazolam immediately afterward failed to exhibit the reactivation effect. A subsequent experiment replicated this finding and further showed that midazolam did not reduce the memory reactivation effect when injected 2 hr after the reminder episode. From this, it appears that alterations in GABAergic neurotransmission may be an underlying process mediating memory reactivation in the infant rat.