The case for Survivin as mitotic regulator
The case for Survivin as mitotic regulator
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DOI：
10.1016/j.ceb.2006.08.016
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发表时间：
2006-12-01
影响因子：
7.5
通讯作者：
Medema, Rene H.
中科院分区：
文献类型：
--
作者：
Lens, Susanne M. A.;Vader, Gerben;Medema, Rene H.
Survivin被认为可以抑制细胞凋亡和调节细胞分裂。然而，关于Survivin是否真的可以执行这些不同的功能以及Survivin是否以某种方式协调凋亡和（异常）细胞分裂仍然存在争议。最近的证据表明，Survivin作为染色体乘客复合物的亚基，其对于正确的染色体分离和胞质分裂是必需的。在该复合物中，有丝分裂激酶Aurora B充当酶核心，而Survivin决定染色体乘客复合物定位。Survivin的这种功能似乎在整个进化过程中是保守的。尽管这些发现并不排除Survivin作为凋亡抑制剂的作用，但它们为Survivin作为有丝分裂调节剂提供了非常有力的证据。
Survivin has been proposed to inhibit apoptosis and to regulate cell division. However, controversy still exists as to whether Survivin can indeed execute these distinct functions and if Survivin somehow coordinates apoptosis and (abnormal) cell division. Recent evidence has demonstrated that Survivin acts as a subunit of the chromosomal passenger complex, which is essential for proper chromosome segregation and cytokinesis. Within this complex, the mitotic kinase Aurora B acts as the enzymatic core, whereas Survivin dictates chromosomal passenger complex localization. This function of Survivin appears to be conserved throughout evolution. Although these findings do not exclude a role for Survivin as apoptosis inhibitor, they make a very strong case for Survivin as mitotic regulator.