Disturbance of cerebral function in people exposed to drinking water contaminated with aluminium sulphate: retrospective study of the Camelford water incident
Disturbance of cerebral function in people exposed to drinking water contaminated with aluminium sulphate: retrospective study of the Camelford water incident
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DOI：
10.1136/bmj.319.7213.807
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发表时间：
1999-09-25
影响因子：
105.7
通讯作者：
Marsh, F
中科院分区：
文献类型：
--
作者：
Altmann, P;Cunningham, J;Marsh, F
目的探讨1988年7月在英国西南部康沃尔郡的Camelford地区饮用20吨硫酸铝污染水的人是否遭受了器质性脑损伤而不是单纯的心理创伤。设计对受影响者的回顾性研究。参与者55名受影响者和15名年龄最接近其中一人但没有接触过硫酸铝的兄弟姐妹。结果受影响者的脑损伤程度与受影响者的脑损伤程度有关。受影响者的脑损伤程度与受影响者的年龄有关主要结果测量各种临床和心理测试，以确定受影响的人的医疗状况和焦虑水平。用全国成人阅读测试、计算机化的心理测试和测量所有参与者闪光和图形视觉诱发电位之间的潜伏期差异评估病前智商（pFSIQ）。结果平均（SE）pFSIQ高于平均值114.4（1.1）。对器质性脑疾病最敏感的精神病学测试是符号数字编码（SDC）测试（正常值100，异常
Objective To establish whether people exposed to drinking water contaminated with 20 tonnes of aluminium sulphate in the Camelford area of Cornwall in the south west of England in July 1988 had suffered organic brain damage as opposed to psychological trauma only.Design Retrospective study of affected people.Participants 55 affected people and 15 siblings nearest in age to one of the group but who had not been exposed to the contaminated water were studied.Main outcome measures Various clinical and psychological tests to determine medical condition and anxiety levels in affected people. Assessment of premorbid IQ (pFSIQ) with the national adult reading test, a computerised battery of psychomotor testing, and measurement of the difference in latencies between the flash and pattern visual evoked potentials in all participants.Results The mean (SE) pFSIQ was above average at 114.4 (1.1). The most sensitive of the psychomotor tests for organic brain disease was the symbol digit coding (SDC) test (normal score 100, abnormal