Pacemakers in aggregation fields of Dictyostelium discoideum: does a single cell suffice?
Pacemakers in aggregation fields of Dictyostelium discoideum: does a single cell suffice?
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盘基网柄菌聚集场中的起搏器：单个细胞就足够了吗？
DOI：
10.1007/bf00276057
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发表时间：
1988
影响因子：
1.9
通讯作者：
Othmer,HG
中科院分区：
文献类型：
--
作者：
DeYoung,G;Monk,PB;Othmer,HG
在本文中，我们解决了以下问题：一个单一的细胞的细胞黏菌Dictyosteelium discoideum作为一个起搏器的聚集阶段？这是否可能由与环AMP远离细胞的扩散和细胞外降解相比，由于自刺激而产生的环AMP的相对重要性决定。我们确定的条件下，一个单一的细胞在一个无限的地方可以发出周期性信号的环AMP使用以前开发的模型信号中继和适应inDictyosteelium。在其他地方，它已被证明，该模型提供了一个准确的代表性的刺激反应行为ofDictyostelium的各种实验条件。
In this paper we address the following question: can a single cell of the cellular slime moldDictyostelium discoideumserve as a pacemaker for the aggregation phase? Whether or not this is possible is determined by the relative importance of cyclic AMP production due to self-stimulation as compared to diffusion of cyclic AMP away from the cell and extracellular degradation. We determine the conditions under which a single cell on an infinite place can emit periodic signals of cyclic AMP using a model developed previously for signal relay and adaptation inDictyostelium. Elsewhere it has been shown that this model provides an accurate representation of the stimulus-response behavior ofDictyosteliumfor a variety of experimental conditions.