The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization.
The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization.
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DOI：
10.1056/nejmoa010035
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发表时间：
2002-03-07
影响因子：
158.5
通讯作者：
Webb, S
中科院分区：
文献类型：
--
作者：
Hansen, M;Kurinczuk, JJ;Webb, S
背景资料：目前尚不清楚是否与使用卵胞浆内单精子注射或体外受精的婴儿有较高的出生缺陷的风险比natural.Methods：我们获得的数据，从三个登记处在西澳大利亚州的出生，出生后辅助受孕，1993年和1997年之间出生的婴儿的主要出生缺陷。我们评估了自然受孕或使用卵胞浆内单精子注射或体外受精的婴儿在一岁时诊断出的主要出生缺陷的患病率。301名婴儿中有26名接受了卵胞浆内单精子注射（8.6%），837名婴儿中有75名通过体外受精受孕在4000名自然受孕的婴儿中，有168名（4.2%; P
Background: It is not known whether infants conceived with use of intracytoplasmic sperm injection or in vitro fertilization have a higher risk of birth defects than infants conceived naturally.Methods: We obtained data from three registries in Western Australia on births, births after assisted conception, and major birth defects in infants born between 1993 and 1997. We assessed the prevalence of major birth defects diagnosed by one year of age in infants conceived naturally or with use of intracytoplasmic sperm injection or in vitro fertilization.Results: Twenty-six of the 301 infants conceived with intracytoplasmic sperm injection (8.6 percent) and 75 of the 837 infants conceived with in vitro fertilization (9.0 percent) had a major birth defect diagnosed by one year of age, as compared with 168 of the 4000 naturally conceived infants (4.2 percent; P