Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling.
Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling.
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DOI：
10.1038/mp.2012.17
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发表时间：
2013-04
影响因子：
11
通讯作者：
Baram, T. Z.
中科院分区：
文献类型：
--
作者：
Chen, Y.;Kramar, E. A.;Chen, L. Y.;Babayan, A. H.;Andres, A. L.;Gall, C. M.;Lynch, G.;Baram, T. Z.
压力在现代生活中无处不在，并对认知和情绪功能产生深远的影响。因此，虽然急性应激增强了记忆，但较长时间的应激会通过尚未解决的机制产生负面影响。我们报告了一个新的，选择性记忆缺陷，由压力引起的校园内在机制。CRH（促肾上腺皮质激素释放激素）是应激时海马神经元释放的一种肽，可抑制突触传递，阻断活动诱导的棘肌动蛋白聚合，损害成年海马脑片的突触可塑性。现场，多光子成像显示了选择性脆弱的薄树突棘这种应激激素，导致小，增强准备兴奋性突触的耗尽。潜在的分子机制需要肌动蛋白调节小GT3，RhoA的激活和信号传导。这些结果暗示了树突棘亚群的选择性丧失是压力对认知和情绪过程的临床重要影响的一种新的结构和功能基础。
Stress is ubiquitous in modern life and exerts profound effects on cognitive and emotional functions. Thus, whereas acute stress enhances memory, longer episodes exert negative effects through as yet unresolved mechanisms. We report a novel, hippocampus-intrinsic mechanism for the selective memory defects that are provoked by stress. CRH (corticotropin-releasing hormone), a peptide released from hippocampal neurons during stress, depressed synaptic transmission, blocked activity-induced polymerization of spine actin and impaired synaptic plasticity in adult hippocampal slices. Live, multiphoton imaging demonstrated a selective vulnerability of thin dendritic spines to this stress hormone, resulting in depletion of small, potentiation-ready excitatory synapses. The underlying molecular mechanisms required activation and signaling of the actin-regulating small GTPase, RhoA. These results implicate the selective loss of dendritic spine sub-populations as a novel structural and functional foundation for the clinically important effects of stress on cognitive and emotional processes.
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DOI：
10.1073/pnas.1003825107
发表时间：
2010-07-20
影响因子：
11.1
作者：
Chen, Yuncai;Rex, Christopher S.;Baram, Tallie Z.
通讯作者：
Baram, Tallie Z.
影响因子：
5.3
作者：
Chen, Lulu Y.;Rex, Christopher S.;Lynch, Gary
通讯作者：
Lynch, Gary
影响因子：
16.2
作者：
Ehlers, Michael D.;Heine, Martin;Choquet, Daniel
通讯作者：
Choquet, Daniel
影响因子：
5.3
作者：
Fedulov, Vadim;Rex, Christopher S.;Lynch, Gary
通讯作者：
Lynch, Gary
影响因子：
5.3
作者：
Chen, YC;Bender, RA;Baram, TZ
通讯作者：
Baram, TZ