Comparison of Two Donor Liver Procurement Methods for Treatment of Pediatric Acute Liver Failure.

Comparison of Two Donor Liver Procurement Methods for Treatment of Pediatric Acute Liver Failure.
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两种供肝方法治疗小儿急性肝衰竭的比较

DOI:
10.3389/fped.2022.816516
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发表时间:
2022
影响因子:
2.6
通讯作者:
Wang Z
Wang Z
中科院分区:
医学3区
文献类型:
--
作者:
Pei J;Shen C;Li R;Tao Y;Lu L;Chen W;Xie X;Wang Z

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评价两种供肝获取方法用于活体肝移植(LDLT)治疗小儿急性肝衰竭(PALF)的差异和疗效。对2016年10月至2020年10月期间在我院接受LDLT的17例PALF患者(男性12例,女性5例),以及使用两种供肝获取方式的供者和受者的预后效果进行分析。供肝组和受供肝组均分为腹腔镜(7例)和开腹(10例)供肝组。在受者中,腹腔镜组发生2例死亡,开腹组发生1例;腹腔镜组发生术后并发症3例,开腹组发生6例。腹腔镜组和开腹组的累计1年和3年生存率分别为80.0%和85.7%。两组术后生存率和并发症发生率无差异。供者中,腹腔镜组的手术时间、术后住院时间、失血量均较开腹组显着减少(P≤0.01)。两个供体组均未发生死亡或严重并发症。在有条件的移植中心进行 PALF 联合 LDLT 治疗时,腹腔镜供肝比开放式供肝值得推荐。
To evaluate the difference and efficacy of two donor liver procurement methods for treatment of pediatric acute liver failure (PALF) by living donor liver transplantation (LDLT). A total of 17 patients (12 men, 5 women) with PALF who underwent LDLT in our hospital between October 2016 and October 2020, and prognostic efficacy of donors and recipients using two donor liver procurement methods were analyzed. The donors and recipients were both divided into laparoscopic (7 cases) and open (10 cases) donor liver procurement groups. In the recipients, two deaths occurred in the laparoscopic group and one in the open group, and there were three postoperative complications in the laparoscopic group and six in the open group. The cumulative 1-year and 3-year survival rates in the laparoscopic group and the open group were 80.0% and 85.7% separately. There was no difference in the postoperative survival and complications rates between the two groups. In the donors, the operation time, postoperative hospital stay, and blood loss of the laparoscopic group was significantly reduced compared with the open group (P ≤ 0.01). No death or serious complication occurred in either donor group. Laparoscopic donor liver procurement is worth recommending than open donor liver procurement for treatment of PALF combined with LDLT in qualified transplant centers.
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