Tumor necrosis factor-alpha levels in blood cord is directly correlated with the body weight of mothers
Tumor necrosis factor-alpha levels in blood cord is directly correlated with the body weight of mothers
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DOI：
10.1002/osp4.47
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发表时间：
2016-06-01
影响因子：
2.2
通讯作者：
Pereira de Araujo, E.
中科院分区：
文献类型：
--
作者：
de Toledo Baldi, E.;Dias Bobbo, V. C.;Pereira de Araujo, E.
研究背景肥胖已成为导致发病率和死亡率上升的主要公共卫生问题。流行病学研究表明，在世界许多地区，儿童和青少年越来越多地受到肥胖症的影响，这导致了对不久的将来的悲观预测。母亲肥胖与后代的代谢紊乱有关，但是没有生物学标记物可以在生命早期检测到来预测后代肥胖的发展。并将这些标记物与9个月龄时的体重相关联。MethodsAnthropometric数据的母亲和婴儿在产前评估，出生时和出生后9个月。在分娩过程中收集了54名肥胖/超重母亲的婴儿和50名瘦母亲的婴儿的脐带血。使用酶联免疫吸附测定法测定血清样品中的肿瘤坏死因子-α（TNF-α）、转化生长因子1 β、单核细胞趋化蛋白-1和2（MCP-1/MCP-2）。相关性进行了评估，使用斯皮尔曼相关系数，并进行了评估，使用非参数曼-惠特尼U-test.ResultsCord血液肿瘤坏死因子-a与产妇体重指数呈正相关。脐带血转化生长因子1 β与婴儿出生时体重呈负相关。有没有生物标志物，预测体重在9个月大的年龄9 months.ConclusionAlthough我们还没有发现一个生物标志物来预测体重增加在9个月大，该研究表明，母亲肥胖暴露婴儿在生命的早期阶段较高的TNF-α水平，这可以影响代谢和炎症参数在成年期。
BackgroundObesity has emerged as major public health problem leading to increased morbidity and mortality. Epidemiological studies indicate that in many regions of the world, children and teenagers are increasingly affected by obesity, which contributes for a pessimistic projection for the near future. Maternal obesity has been implicated in metabolic disorders of the offspring, but there are no biological markers that can be detected early on life that predict the development of obesity in the offspring.ObjectiveTo evaluate the expression of inflammatory markers in the umbilical cord blood of babies of mothers with obesity/overweight, and correlate these markers with the body weight at age 9 months.MethodsAnthropometric data of mothers and babies were obtained during prenatal evaluation, at birth and 9 months after birth. Cord blood was collected during delivery of 54 babies from mothers with obesity/overweight and of 50 babies from lean mothers. Tumour necrosis factor-alpha (TNF-alpha), transforming growth factor 1 beta, monocyte chemoattractant protein-1 and 2 (MCP-1/MCP-2) were determined in serum samples using enzyme-linked immunosorbent assay methods. Correlations were evaluated using the Spearman correlation coefficient, and comparisons were evaluated using the non-parametric Mann-Whitney U-test.ResultsCord blood TNF-a was positively correlated with maternal body mass index. There was an inverse correlation between cord blood transforming growth factor 1 beta and baby body weight at birth. There was no biological marker that predicted body weight at age 9 months.ConclusionAlthough we have not found a biological marker to predict increased body weight at 9 months of age, the study shows that maternal obesity exposes the baby to higher TNF-a level in the early stages of life, and this can affect metabolic and inflammatory parameters during adulthood.