Olfactory Deficits and Amyloid-β Burden in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Aging: A PiB PET Study
Olfactory Deficits and Amyloid-β Burden in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Aging: A PiB PET Study
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DOI：
10.3233/jad-2010-100696
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发表时间：
2010-01-01
影响因子：
4
通讯作者：
Savage, Greg
中科院分区：
文献类型：
--
作者：
Bahar-Fuchs, Alex;Chetelat, Gael;Savage, Greg
在遗忘性轻度认知障碍 (aMCI) 患者中观察到嗅觉缺陷和淀粉样蛋白 (Aβ) 负担增加；这两个因素都可以预测阿尔茨海默病（AD）。我们使用匹兹堡化合物 B (PiB) PET 探讨了嗅觉识别是否与体内 A β 负荷测量相关。 19 名对照组、24 名 aMCI 和 20 名 AD 参与者完成了嗅觉识别任务并接受了 PiB PET 扫描。对照参与者在嗅觉识别方面表现更好，并且比 aMCI 患者表现出更低的 PiB 结合。当将所有组集中在一起时，这两个因素之间存在显着相关性，但单独考虑每个组时则不存在显着相关性。此外，PiB 阳性和 PiB 阴性的 aMCI 参与者之间的嗅觉识别评分没有差异。我们得出的结论是，AD 相关的嗅觉识别缺陷与 A beta 负担没有直接关系。
Olfactory deficits and increased amyloid-beta (A beta) burden are observed in people with amnestic mild cognitive impairment (aMCI); both factors may be predictive of Alzheimer's disease (AD). We explored whether olfactory identification is related to in vivo measures of A beta burden using Pittsburgh Compound B (PiB) PET. Nineteen control, 24 aMCI, and 20 AD participants completed an olfactory identification task and underwent PiB PET scanning. Control participants performed better on olfactory identification and showed lower PiB binding than aMCI patients. There was a significant correlation between both factors when pooling all groups together but not when considering each group separately. In addition, the olfactory identification score did not differ between aMCI participants who were PiB-positive and those who were PiB-negative. We conclude that AD-related olfactory identification deficits are not directly related to A beta burden.