The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study
The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study
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DOI：
10.1186/s40463-020-00410-z
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发表时间：
2020-04-06
影响因子：
3.4
通讯作者：
Ho, Kuen-Yao
中科院分区：
文献类型：
--
作者：
Chang, Ning-Chia;Yang, Hua-Ling;Ho, Kuen-Yao
背景年龄相关性听力障碍(ARHI)是老年人群中的一种主要残疾。慢性炎症是ARHI发生发展的重要因素。白介素1(IL-1)在炎症反应中起关键作用，可能与ARHI有关。本研究旨在分析台湾地区老年人群中白介素1受体基因单核苷酸多态(SNPs)与ARHI的关系。方法招募65岁的受试者进行听力测试和基因分析。计算高音听力水平的双侧纯音平均(PTA)以评估ARHI。对182例ARHI易感(病例)和176例ARHI抵抗(对照组)受试者的IL-1受体1型基因(IL1R1)(rs3917225和rs2234650)和2型基因(IL1R2)(rs4141134和rs2071008)的单核苷酸多态与ARHI的相关性进行了分析。结果调整性别、年龄和噪声暴露后，IL1R1rs3917225的G等位基因发生ARHI的风险降低。在所有遗传模型中，IL1R1rs3917225的GG基因型和隐性模型中的IL1R2 rs2071008的TT型也显示出调整后的ARHI风险降低。结论IL1R1和IL1R2基因多态性可能与老年人ARHI发病风险降低有关。
Background Age-related hearing impairment (ARHI) is a major disability among the elder population. Chronic inflammation is an important factor in the development of ARHI. Interleukin-1 (IL-1) plays a key role in inflammation and may be associated with ARHI. The aim of this study is to analyze the associations of single nucleotide polymorphisms (SNPs) of IL-1 receptor genes with ARHI in an elderly population in Taiwan. Method Participants >= 65 years of age were recruited for audiometric tests and genetic analyses. The bilateral pure-tone average (PTA) of high-tone hearing levels was calculated for ARHI evaluation. The associations of SNPs of the IL-1 receptor type 1 gene (IL1R1) (rs3917225 and rs2234650) and type 2 gene (IL1R2) (rs4141134 and rs2071008) with ARHI were analyzed in 182 ARHI-susceptible (case) and 176 ARHI-resistant (control) participants. Results The G allele of IL1R1 rs3917225 showed a decreased risk of ARHI after adjustments for sex, age, and noise exposure. The GG genotype of IL1R1 rs3917225 in all hereditary models and the TT genotype of IL1R2 rs2071008 in the recessive model also showed decreased risks of ARHI after adjustments. Conclusion These findings suggest that IL1R1 and IL1R2 polymorphisms may contribute to the decreased risk of ARHI in the elderly population.