Distinctive RNA expression profiles in blood associated with Alzheimer disease after accounting for white matter hyperintensities.
Distinctive RNA expression profiles in blood associated with Alzheimer disease after accounting for white matter hyperintensities.
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DOI：
10.1097/wad.0000000000000022
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发表时间：
2014-07
影响因子：
2.1
通讯作者：
Sharp FR
中科院分区：
文献类型：
--
作者：
Bai Z;Stamova B;Xu H;Ander BP;Wang J;Jickling GC;Zhan X;Liu D;Han G;Jin LW;DeCarli C;Lei H;Sharp FR
确定阿尔茨海默病（AD）中的RNA转录组将有助于了解疾病机制并提供生物标志物。虽然研究了AD血液转录组，但未考虑白色高信号（WMH）的影响。本研究调查了AD血液转录组并解释了WMH。在全基因组微阵列上处理来自全血的RNA。293个探针组在AD与对照中差异表达，其中5个对于WMH状态是显著的。288个AD特异性探针集以87.5%的灵敏度和90.5%的特异性对受试者进行分类。它们代表了188个基因，其中29个在先前的AD血液中报道，89个在AD脑研究中报道。调节的血液基因包括MMP9、MME（脑啡肽酶）、TGFβ1、CA 4、OCLN、ATM、TGM3、IGFR 2、NOV、RNF213、BMX、LRRN 1、CAMK 2G、INSR、CTSD、SORCS 1、SORL 1和TANC 2。无论WMH状态如何，AD血液中的RNA表达都会改变。一些基因与AD大脑共享。
Defining the RNA transcriptome in Alzheimer’s Disease (AD) will help understand disease mechanisms and provide biomarkers. Though the AD blood transcriptome has been studied, effects of white matter hyperintensities (WMH) were not considered. This study investigated the AD blood transcriptome and accounted for WMH. RNA from whole blood was processed on whole-genome microarrays. 293 probe sets were differentially expressed in AD versus controls, 5 of which were significant for WMH status. The 288 AD-specific probe-sets classified subjects with 87.5% sensitivity and 90.5% specificity. They represented 188 genes of which 29 have been reported in prior AD blood and 89 in AD brain studies. Regulated blood genes included MMP9, MME (Neprilysin), TGFβ1, CA4, OCLN, ATM, TGM3, IGFR2, NOV, RNF213, BMX, LRRN1, CAMK2G, INSR, CTSD, SORCS1, SORL1 and TANC2. RNA expression is altered in AD blood irrespective of WMH status. Some genes are shared with AD brain.