Human infection caused by Streptococcus suis serotype 2 in China: report of two cases and epidemic distribution based on sequence type
Human infection caused by Streptococcus suis serotype 2 in China: report of two cases and epidemic distribution based on sequence type
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DOI：
10.1186/s12879-020-4943-x
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发表时间：
2020-03-14
影响因子：
3.7
通讯作者：
Gu, Bing
中科院分区：
文献类型：
--
作者：
Jiang, Fei;Guo, Jingjing;Gu, Bing
背景猪链球菌是一种人畜共患病原体，可引起猪的严重全身性感染和与猪或猪肉制品接触的人的职业性感染。在中国，它已经引起了两次人感染的暴发，自上次以来对猪链球菌的监测一直在进行中。本研究报告了猪流感。这两名患者的工作都与猪肉贸易有关，猪肉贸易是S。猪感染。经过长期的头孢曲松治疗，结果是有利的，但一名患者留下了轻度听力损失。2株分离株经测序鉴定为（ST）7型、S.猪链球菌2型（SS2）是我国最流行的猪链球菌病之一，在我国曾引起两次猪链球菌病暴发。全基因组测序（WGS）结果显示，本研究中的两株散发性ST7 SS2分离株与代表性流行性强毒株在基因组结构和序列上具有高度的一致性。它们之间的主要区别是两个散发的ST7 SS2分离物缺乏称为凝集素受体的毒力因子和89K致病岛（派），其在链球菌中毒性休克综合征（STSS）的发病机制中起重要作用。本文对人感染沙门氏菌的STs的研究进展作一综述。在中国，已经完成。结果表明，ST 1和ST 7仍是主要的ST，并在不同省份成功发现了几种新的ST。猪在中国
BackgroundStreptococcus suis is a zoonotic pathogen that causes serious systemic infections in pigs and occupation-related infections in humans who contact with pigs or pork products. In China, it has caused two outbreaks of human infection and surveillance for S.suis has been ongoing since last time.Case presentationTwo cases of meningitis and sepsis caused by S. suis were reported in this study. Both patients work in relation to the pork trade, a risk factor for S. suis infection. The outcome was favorable after a prolonged ceftriaxone therapy but one patient was left with mild hearing loss. Two isolates were identified as sequencing type (ST) 7, S. suis serotype 2 (SS2), which is one the most prevalent and cause two outbreaks in China. Whole-genome sequencing (WGS) revealed that a high degree identity was noted in the genome organizations and sequences between two sporadic ST7 SS2 isolates in this study and representative epidemic virulent isolates. Major differences among them are two sporadic ST7 SS2 isolates lacked a virulence factor called agglutinin receptor and an 89K pathogenicity island (PAI), which plays important role in the pathogenesis of streptococcal toxic shock syndrome (STSS). A summary about STs of human infection with S. suis in China was completed. The result showed ST1 and ST7 were still the major STs and several novel STs were successfully discovered in different provinces.ConclusionsOur results enhanced the understanding of the ability to cause life-threatening infections in humans and the distribution and evolution of the S. suis in China.