Increased mu opioid receptor binding detected by PET in cocaine-dependent men is associated with cocaine craving.
Increased mu opioid receptor binding detected by PET in cocaine-dependent men is associated with cocaine craving.
复制标题
PET 检测到可卡因依赖男性中 mu 阿片受体结合增加与可卡因渴望有关。
DOI：
10.1038/nm1196-1225
复制
发表时间：
1996
期刊：
影响因子：
82.9
通讯作者：
Frost,JJ
中科院分区：
文献类型：
--
作者：
Zubieta,JK;Gorelick,DA;Stauffer,R;Ravert,HT;Dannals,RF;Frost,JJ
The endogenous opioid system has been recently implicated in the reinforcing actions of cocaine and other addictive drugs. In this study we examined μ opioid receptor binding in ten cocaine–dependent men and seven nonaddicted controls using positron emission tomography and [11C]carfentanil. Mu opioid binding was increased in several brain regions of the cocaine addicts studied 1–4 days after their last use of cocaine. Binding was positively correlated with the severity of cocaine craving experienced at the time. The upregulation of μ opioid receptor binding persisted after 4 weeks of monitored cocaine abstinence. These findings demonstrate for the first time the involvement of the endogenous opioid system in cocaine dependence and cocaine craving in living human subjects.
