Measurement and scan reproducibility of parameters of intravoxel incoherent motion in renal tumor and normal renal parenchyma: a preliminary research at 3.0 T MR
Measurement and scan reproducibility of parameters of intravoxel incoherent motion in renal tumor and normal renal parenchyma: a preliminary research at 3.0 T MR
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肾肿瘤和正常肾实质体素内不相干运动参数的测量和扫描再现性：3.0 T MR 的初步研究
DOI：
10.1007/s00261-017-1361-7
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发表时间：
2018-07-01
影响因子：
2.4
通讯作者：
Ye, Huiyi
中科院分区：
文献类型：
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作者：
Pan, Jingjing;Zhang, Hongtao;Ye, Huiyi
前瞻性地评估肾肿瘤、正常肾皮质和髓质的体素内非相干运动(IVIM)参数的测量和扫描的可重复性。对25例肾肿瘤(20例肾细胞癌、1例尿路上皮癌、3例血管肌脂瘤和1例嗜酸细胞瘤)患者进行了两次IVIM1和IVIM2扫描，扫描时间均为3.0T，平均年龄56.7岁，扫描时间为24~48h。使用配对t检验评估两个IVIM组之间的参数差异以及观察者内、观察者间和扫描-再扫描的差异。通过测量变异系数和Bland-Altman一致性限来评估观察者内、观察者间和扫描-再扫描的重复性。肾肿瘤、正常肾皮质和髓质的观察者内重复性良好(表观扩散系数；变异系数：3.45%~5.34%，BA-LA：-14%~18%)和D(CV：3.65%~6.04%，BA-LA：-18%~19%)，差于f(CV：11.96%~16.08%，BA-LA：-76.4%~92.1%，IVIM1中延髓的变异系数为32.59%，BA-LA为-76.4%~92.1%)，D*较差(CV：25.0%~75.4%)，BA-LA：-111%至150%)。观察者间重复性分析的顺序相同。扫描-再扫描的重复性是三个参数中最差的。肾髓质的重复性比肾肿瘤和正常皮质差。IVIM2的重复性好于IVIM1。IVIM的ADC和D重复性好，F好，D*差。肾肿瘤、正常肾皮质和髓质的ADC和D重复性好。D*的可靠性有限，扫描-重新扫描的重复性有待提高。
To prospectively estimate measurement and scan reproducibility of parameters of intravoxel incoherent motion (IVIM) in renal tumors, normal renal cortex, and medulla.Twenty-four consecutive patients (twelve males and twelve females; median age 56.7 years, range 32-71 years) with 25 renal tumors (20 renal cell carcinomas, one urothelium carcinoma, three angiomyolipomas, and one oncocytoma) were examined twice using IVIM1 and IVIM2 with 9 and 16 b values, respectively, at 3.0 T. All the patients were re-scanned in 24-48 h. Regions of interest (ROIs) were placed in solid part of tumor, normal cortex, and medulla to derive IVIM parameters D (true diffusion coefficient), D* (pseudodiffusion coefficient), and f (perfusion fraction of pseudodiffusion). Differences in parameters between two IVIM sets and intra-observer, inter-observer, and scan-rescan differences were assessed using paired t tests. Intra-observer, inter-observer, and scan-rescan reproducibility were assessed by measuring coefficient of variation and Bland-Altman limits of agreements.Intra-observer reproducibility of renal tumors, normal renal cortex, and medulla was excellent for apparent diffusion coefficient (ADC; CV: 3.45%-5.34%, BA-LA: -14% to 18%) and D (CV: 3.65% to 6.04%, BA-LA: -18% to 19%), good for f (CV: 11.96%-16.08%, BA-LA: -76.4% to 92.1% except f of medulla with CV of 32.59% and BA-LA of -76.4% to 92.1% in IVIM1), and poor for D* (CV: 25.0% to 75.4%, BA-LA: -111% to 150%). The same order was in inter-observer reproducibility analysis. Scan-rescan reproducibility was the worst of the three parameters. Renal medulla showed worse reproducibility than renal tumors and the normal cortex. The metrics of IVIM2 had better reproducibility than IVIM1.Excellent reproducibility evaluation for ADC and D, good for f, and poor for D* derived from IVIM was performed in renal tumors, normal renal cortex, and medulla. D* has limited reliability and scan-rescan reproducibility should be improved.