MYELOPEROXIDASE - CONTRIBUTION TO MICROBICIDAL ACTIVITY OF INTACT LEUKOCYTES
MYELOPEROXIDASE - CONTRIBUTION TO MICROBICIDAL ACTIVITY OF INTACT LEUKOCYTES
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DOI：
10.1126/science.169.3950.1095
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发表时间：
1970-01-01
期刊：
影响因子：
56.9
通讯作者：
KLEBANOFF, SJ
中科院分区：
文献类型：
--
作者：
KLEBANOFF, SJ
叠氮化物和氰化物在较小程度上抑制髓过氧化物酶和完整正常白细胞的杀微生物活性，但它们对过氧化物酶阴性白细胞几乎没有影响。叠氮化物敏感的（过氧化物酶依赖的？）系统对正常白细胞的总杀微生物活性是相当大的。过氧化物酶阴性的白细胞比正常白细胞中叠氮化物不敏感的抗菌系统更高度发达，从而表明适应。
Azide and, to a lesser extent, cyanide inhibit the microbicidal activity of myeloperoxidase and of intact normal leukocytes, but they have little or no effect on peroxidase-negative leukocytes. The contribution of the azide-sensitive (peroxidase-dependent?) systems to the total microbicidal activity of normal leukocytes is considerable. The azide-insensitive antimicrobial systems are more highly developed in peroxidase-negative leukocytes than in normal leukocytes, thus suggesting an adaption.