HEPATITIS-C VIRUS-INFECTION IS AN ADDITIVE RISK FACTOR FOR DEVELOPMENT OF HEPATOCELLULAR-CARCINOMA IN PATIENTS WITH CIRRHOSIS
HEPATITIS-C VIRUS-INFECTION IS AN ADDITIVE RISK FACTOR FOR DEVELOPMENT OF HEPATOCELLULAR-CARCINOMA IN PATIENTS WITH CIRRHOSIS
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DOI：
10.1016/0168-8278(91)90841-x
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发表时间：
1991-05-01
影响因子：
25.7
通讯作者：
COLTORTI, M
中科院分区：
文献类型：
--
作者：
CAPORASO, N;ROMANO, M;COLTORTI, M
本研究的目的是评估丙型肝炎病毒是否在肝硬变患者的肝细胞癌的发生中起作用。还评估了年龄、性别、酗酒和其他肝炎病毒感染的作用，如乙肝病毒和Delta病毒。我们发现，肝细胞癌合并肝硬化组患者的平均年龄和男女比例显著高于单纯肝硬化组。此外，与肝硬变患者相比，肝细胞癌患者的丙型肝炎病毒感染率更高。进一步，通过多元Logistic回归分析，我们评估了各变量在肝细胞癌发生发展中的独立作用。年龄、男性和抗-丙型肝炎病毒阳性评估的较小程度的丙型肝炎病毒感染是唯一与肝细胞癌的发展显著相关的危险因素。此外，当从统计模型中排除年龄和性别时，丙型肝炎病毒感染，而不是乙肝病毒、HDV和酗酒，似乎与肝细胞癌有关。综上所述，根据这些数据，年龄和男性是肝硬变患者发生肝细胞癌的最重要因素。丙型肝炎病毒，至少在地中海地区，可能在患有肝硬变的患者中作为肝细胞癌的附加危险因素发挥作用。
The aim of the present study was to evaluate whether hepatitis C virus plays any role in the development of hepatocellular carcinoma in cirrhotic patients. The role of age, sex, alcohol abuse, and infection by other hepatitic viruses, such as hepatitis B and Delta viruses, was also assessed. We found that mean age and male/female ratio were significantly higher in patients with HCC plus liver cirrhosis than in those with liver cirrhosis alone. Also, the prevalence of HCV infection was found to be higher in HCC patients compared to cirrhotics. Further, by means of multiple logistic regression, we evaluated the independent role of each variable in the development of HCC. Age, male sex, and to a lesser degree, HCV infection, as assessed by anti-HCV positivity, were the only risk factors which significantly correlated with the development of HCC. Moreover, when age and sex were excluded from the statistical model, HCV infection, but not HBV, HDV, and alcohol abuse, appeared to be associated with HCC. In conclusion, based on these data, age and male sex are the most important factors for the development of hepatocellular carcinoma in cirrhotic patients. Hepatitis C virus, at least in the Mediterranean area, may play a role as an additive risk factor of HCC in patients suffering from liver cirrhosis.