Human Connectomics across the Life Span.
Human Connectomics across the Life Span.
复制标题
整个生命周期的人类连接组学。
DOI：
10.1016/j.tics.2016.10.005
复制
发表时间：
2017
影响因子：
19.9
通讯作者：
Milham,MichaelP
中科院分区：
文献类型：
--
作者：
Zuo,Xi-Nian;He,Ye;Betzel,RichardF;Colcombe,Stan;Sporns,Olaf;Milham,MichaelP
连接组学通过将网络科学整合到人类生命周期不同阶段的研究中，增强了我们对神经认知发展和衰退的理解。然而，这些研究通常是独立进行的，错过了在整个生命周期中测试动态大脑组织的综合模型的机会。在这篇综述文章中，我们调查了寿命连接组学的实证研究结果，并提出了一个生成框架，用于在人类寿命内对连接组进行计算建模。这个框架强调了最初的发现，即在整个生命周期中，人类连接体逐渐从“解剖学驱动”的组织转变为更具“拓扑学”的组织。最后，我们认为最近的进展是有希望提供一个整合和系统的角度来看，人类大脑的可塑性，以及强调的陷阱和挑战。
Connectomics has enhanced our understanding of neurocognitive development and decline by the integration of network sciences into studies across different stages of the human life span. However, these studies commonly occurred independently, missing the opportunity to test integrated models of the dynamical brain organization across the entire life span. In this review article, we survey empirical findings in life-span connectomics and propose a generative framework for computationally modeling the connectome over the human life span. This framework highlights initial findings that across the life span, the human connectome gradually shifts from an ‘anatomically driven' organization to one that is more ‘topological'. Finally, we consider recent advances that are promising to provide an integrative and systems perspective of human brain plasticity as well as underscore the pitfalls and challenges.