Th17 cells in autoimmune and infectious diseases.
Th17 cells in autoimmune and infectious diseases.
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DOI：
10.1155/2014/651503
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发表时间：
2014
影响因子：
2
通讯作者：
Vibanco-Pérez N
中科院分区：
文献类型：
--
作者：
Zambrano-Zaragoza JF;Romo-Martínez EJ;Durán-Avelar Mde J;García-Magallanes N;Vibanco-Pérez N
CD 4 T细胞介导的免疫是Th 1和Th 2细胞不同谱系之间的平衡的观点已经发生了巨大变化。IL-17家族细胞因子的鉴定和IL-23介导产生IL-17的T细胞的扩增的事实揭示了一种新的Th细胞亚群，称为Th 17细胞，其已经作为第三种独立的T细胞亚群出现，其可能在保护免受某些细胞外病原体的侵害中发挥重要作用。此外，由于Th 17细胞与炎症性疾病和自身免疫性疾病的密切相关性，Th 17细胞已被广泛分析。此外，它们似乎对控制这些疾病至关重要。与Th 1和Th 2细胞类似，Th 17细胞需要特异性细胞因子和转录因子来分化。Th 17细胞已被表征为导致许多自身免疫性疾病发展的主要致病性Th细胞群体之一，并且它们被IL-23增强和稳定。本文就Th 17细胞的特性、细胞因子及其来源，以及它们在感染性疾病和自身免疫性疾病中的作用作一综述。
The view of CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed dramatically. Identification of the IL-17 family of cytokines and of the fact that IL-23 mediates the expansion of IL-17-producing T cells uncovered a new subset of Th cells designated Th17 cells, which have emerged as a third independent T-cell subset that may play an essential role in protection against certain extracellular pathogens. Moreover, Th17 cells have been extensively analyzed because of their strong association with inflammatory disorders and autoimmune diseases. Also, they appear to be critical for controlling these disorders. Similar to Th1 and Th2 cells, Th17 cells require specific cytokines and transcription factors for their differentiation. Th17 cells have been characterized as one of the major pathogenic Th cell populations underlying the development of many autoimmune diseases, and they are enhanced and stabilized by IL-23. The characteristics of Th17 cells, cytokines, and their sources, as well as their role in infectious and autoimmune diseases, are discussed in this review.