Aging and Lung Injury Repair: A Role for Bone Marrow Derived Mesenchymal Stem Cells
Aging and Lung Injury Repair: A Role for Bone Marrow Derived Mesenchymal Stem Cells
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DOI：
10.1002/jcb.21890
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发表时间：
2008-10-15
影响因子：
4
通讯作者：
Rojas, Mauricio
中科院分区：
文献类型：
--
作者：
Mora, Ana L.;Rojas, Mauricio
肺纤维化的发病率随年龄增长而增加。衰老与细胞内和细胞外环境的改变有关，包括细胞外基质的改变、氧化还原状态的失衡、衰老细胞的积累和骨髓间充质干细胞募集的潜在改变。肺和骨髓祖细胞中这些衰老相关改变的组合可能是老年个体对肺纤维化的更高易感性的原因。在制定控制肺损伤和纤维化的治疗干预措施时，必须考虑对这些年龄相关变化的理解。J.细胞。105：641-647，2008. (c)2008 Wiley-Liss，Inc.
The incidence of lung fibrosis increases with age. Aging is associated with modifications in the intracellular and extracellular environment including alteration of the extracellular matrix, imbalance of the redox state, accumulation of senescent cells and potential alteration of the recruitment of bone marrow mesenchymal stem cells. The combination of these senescence-related alterations in the lung and in bone marrow progenitor cells might be responsible of the higher susceptibility to lung fibrosis in elderly individuals. The understanding of these age related changes must be considered in the rationale for the development of therapeutic interventions to control lung injury and fibrosis. J. Cell. Biochem. 105: 641-647, 2008. (c) 2008 Wiley-Liss, Inc.