Telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: Do they measure the same thing?
Telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: Do they measure the same thing?
复制标题
DOI：
10.1101/071373
复制
发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
D. W. Belsky;T. Moffitt;Alan A. Cohen;David L Corcoran;Steve Horvath;Morgan E. Levine;Joseph A. Prinz-Jose
中科院分区：
文献类型：
--
作者：
D. W. Belsky;T. Moffitt;Alan A. Cohen;David L Corcoran;Steve Horvath;Morgan E. Levine;Joseph A. Prinz-Jose
老年科学假说认为，延缓衰老的生物过程的疗法可以预防疾病。为了在人类中测试这种“老年保护”疗法，需要延长无病寿命的替代终点。量化生物老化的方法可以提供这样的替代终点，但不同的方法还没有在同一个人中进行系统的评估。我们在达尼丁研究中研究了964名中年人的七种生物衰老指标：端粒长度、三种表观遗传时钟和三种生物标志物复合物。这些不同的生物老化措施之间的协议是低的。我们还比较了生物衰老指标与老年保护疗法试图改变的结果之间的关联：身体功能，认知能力下降和衰老的主观迹象。71-CpG表观遗传时钟和生物标志物复合物与这些结果一致相关。尺寸适中。生物老化的量化是一个年轻的领域。下一步是走向系统的评估和方法的改进。
The geroscience hypothesis posits that therapies to retard biological processes of aging can prevent disease. To test such “geroprotective” therapies in humans, surrogate endpoints are needed for extension of disease-free lifespan. Methods to quantify biological aging could provide such surrogate endpoints, but different methods have not been systematically evaluated in the same humans. We studied seven measures of biological aging in 964 middle-aged humans in the Dunedin Study: telomere-length, three epigenetic-clocks, and three biomarker-composites. Agreement between these different measures of biological aging was low. We also compared associations between biological aging measures and outcomes that geroprotective therapies will seek to modify: physical functioning, cognitive decline, and subjective signs of aging. The 71-CpG epigenetic clock and the biomarker composites were consistently related to these outcomes. Effect-sizes were modest. Quantification of biological aging is a young field. Next steps are to move toward systematic evaluation and refinement of methods.