Phosphorylation events during Müllerian duct regression.
Phosphorylation events during Müllerian duct regression.
复制标题
苗勒氏管消退过程中的磷酸化事件。
DOI：
10.1126/science.6607531
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Budzik,GP
中科院分区：
文献类型：
--
作者：
Hutson,JM;Fallat,ME;Kamagata,S;Donahoe,PK;Budzik,GP
在不存在苗勒管抑制物质的情况下，用氟化钠刺激离体胎鼠苗勒管的退行。在锰离子存在下，苗勒管抑制物质的作用可被钒酸钠、5′-三磷酸腺苷和几种相关核苷酸抑制。表皮生长因子特异性抑制该物质，但仅与锰离子存在。胰岛素、血小板衍生生长因子和神经生长因子没有影响。这些结果表明，膜蛋白的去磷酸化介导苗勒管抑制物质的作用。
Regression of the fetal rat Müllerian duct in vitro was stimulated by sodium fluoride in the absence of Müllerian inhibiting substance. The action of Müllerian inhibiting substance was inhibited by sodium vanadate, adenosine 5′-triphosphate, and several related nucleotides in the presence of manganese ions. Epidermal growth factor specifically inhibited the substance, but only with manganese ions present. Insulin, platelet-derived growth factor, and nerve growth factor had no effect. These results suggest that dephosphorylation of membrane proteins mediates the action of Müllerian inhibiting substance.