Neonatal amphetamine exposure and hippocampus-mediated behaviors.
Neonatal amphetamine exposure and hippocampus-mediated behaviors.
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新生儿安非他明暴露和海马介导的行为。
DOI：
10.1016/j.nlm.2008.12.005
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发表时间：
2009
影响因子：
2.7
通讯作者：
Chen,Wei-JungA
中科院分区：
文献类型：
--
作者：
Smith,AndrewM;Chen,Wei-JungA
以前的研究将怀孕期间使用安非他明与受影响婴儿行为发育的变化联系起来，大大增加了社会对育龄妇女使用安非他明的关注程度。本研究的目的是调查是否暴露于d-安非他明硫酸盐在大脑生长突增期，大脑发育的最动态的时期，改变在青春期前和年轻的成年校园介导的行为。从出生后第4-9天（PD），对Sprague-Dawley大鼠幼仔灌胃给予含0、5、15或25 mg/kg/天安非他明的配方奶粉。断奶后，新生儿安非他明暴露对海马介导的行为的影响进行了评估，使用开放领域，水迷宫，和条件性味觉厌恶行为任务。这些行为测试的结果表明，虽然安非他明暴露在大脑生长突增改变行为在开放领域的测试，它不干扰性能无论是水迷宫或条件性味觉厌恶范式。这些结果提供推测，新生儿安非他明暴露对海马介导的行为的影响可能与“时间”（药物暴露时间）和“区域”（海马不同区域）脆弱性问题之间的相互作用有关。
Previous studies linking amphetamine use during pregnancy to changes in the behavioral development of affected infants have greatly increased society’s level of concern regarding amphetamine use by women of reproductive age. The aim of this study was to investigate whether exposure to d-amphetamine sulfate during the brain growth spurt, the most dynamic period of brain development, alters hippocampus-mediated behaviors during both pre-adolescence and young adulthood. Sprague–Dawley rat pups were intragastrically administered a milk formula containing 0, 5, 15 or 25mg/kg/day of amphetamine from postnatal day (PD) 4–9. Following weaning, the effects of neonatal amphetamine exposure on hippocampus-mediated behaviors were assessed using the open-field, the water maze, and the conditioned taste aversion behavioral tasks. Results from these behavioral tests revealed that while amphetamine exposure during the brain growth spurt alters behaviors in open-field testing, it does not interfere with performance in either the water maze or the conditioned taste aversion paradigm. These results offer speculation that the effects of neonatal amphetamine exposure on hippocampus-mediated behaviors may be related to interactions between the “temporal” (time of drug exposure) and “regional” (different regions of the hippocampus) vulnerability issues.