Collective behavior in cancer cell populations
Collective behavior in cancer cell populations
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DOI：
10.1002/bies.200800084
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发表时间：
2009-02-01
期刊：
影响因子：
4
通讯作者：
Couzin, Iain D.
中科院分区：
文献类型：
--
作者：
Deisboeck, Thomas S.;Couzin, Iain D.
近年来，恶性肿瘤代表了复杂的动态和自组织的生物系统。此外，越来越多的证据表明，在恶性肿瘤的侵袭和转移过程中，集体细胞迁移是常见的。在这里，我们认为，癌症系统可能能够发展多细胞集体模式，类似于从其他生物系统已知的进化适应行为，包括集体感知环境条件和集体决策。我们提出了一个概念，这些属性如何在肿瘤中出现，以及为什么这种群体样模式的出现会赋予肿瘤时空扩张有利的属性，因此，为什么理解并最终靶向这种集体性应该对基础和临床癌症研究都感兴趣。
In recent years the argument has been made that malignant tumors represent complex dynamic and self-organizing biosystems. Furthermore, there is increasing evidence that collective cell migration is common during invasion and metastasis of malignant tumors. Here, we argue that cancer systems may be capable of developing multicellular collective patterns that resemble evolved adaptive behavior known from other biological systems including collective sensing of environmental conditions and collective decision-making. We present a concept as to how these properties could arise in tumors and why the emergence of such swarm-like patterns would confer advantageous properties to the spatio-temporal expansion of tumors, and consequently, why understanding and ultimately targeting such collectivity should be of interest for basic and clinical cancer research alike.