Biodegradable polymer scaffold for tissue engineering
Biodegradable polymer scaffold for tissue engineering
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DOI：
10.4028/www.scientific.net/kem.288-289.59
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Chen, G
中科院分区：
文献类型：
--
作者：
Tateishi, T;Chen, G
以冰颗粒为致孔剂制备了生物可降解多孔支架。通过在合成聚合物海绵或网的孔隙或间隙中形成胶原微海绵，已经开发了一种新型的杂化生物可降解多孔支架。合成聚合物、胶原蛋白和羟基磷灰石的混合海绵已被开发用于硬组织工程。牛关节软骨样组织已经通过在PLGA-胶原支架中培养软骨细胞来工程化。
A new method for the preparation of biodegradable porous scaffolds has been developed by using pre-prepared ice particulates as porogen material. A novel kind of hybrid biodegradable porous scaffold has been developed by forming collagen microsponges in the pores or interstices of a synthetic polymer sponge or mesh. A hybrid sponge of synthetic polymer, collagen and hydroxyapatite has been developed for hard tissue engineering. Bovine articular cartilage-like tissue has been engineered by culturing chondrocytes in the PLGA-collagen scaffolds.