Inhibition of ornithine decarboxylase activity by small doses of alpha-difluoromethylornithine.
Inhibition of ornithine decarboxylase activity by small doses of alpha-difluoromethylornithine.
复制标题
小剂量的α-二氟甲基鸟氨酸抑制鸟氨酸脱羧酶活性。
DOI：
10.1016/0304-3835(85)90042-4
复制
发表时间：
1985
期刊：
影响因子：
9.7
通讯作者：
Verma,AK
中科院分区：
文献类型：
--
作者：
Loprinzi,CL;Verma,AK
The induction of ornithine decarboxylase (ODC) appears to be an important aspect of carcinogenesis. Agents which inhibit ODC have been shown to preclude cancer formation in many organ systems. We studied the dose and dose schedule of α-difluoromethylornithine (DFMO), a suicide inhibitor of ODC, needed to effectively inhibit ODC activity in mice. Our data demonstrate that doses many-fold lower than comparable maximal tolerated doses in humans can inhibit ODC activity in mice. In addition, a simplified, once daily dosage of DFMO appears adequate.
