Evaluation of Anosognosia in Alzheimer's Disease Using the Symptoms of Early Dementia-11 Questionnaire (SED-11Q).
Evaluation of Anosognosia in Alzheimer's Disease Using the Symptoms of Early Dementia-11 Questionnaire (SED-11Q).
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DOI：
10.1159/000355367
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发表时间：
2013
影响因子：
2.3
通讯作者：
Yamaguchi H
中科院分区：
文献类型：
--
作者：
Maki Y;Yamaguchi T;Yamaguchi H
目的是提出一个简单的方法来评估病感失认在阿尔茨海默病（AD）使用早期痴呆症状-11问卷（SED-11 Q），一个简短的基于信息的筛选问卷，用于识别痴呆。参与者为107名老年人：13名临床痴呆评分（CDR）为0.5，73名轻度AD为CDR 1，21名中度AD为CDR 2。患者和照顾者独立回答SED-11 Q，差异程度表明疾病感缺失的严重程度。评分如下：CDR 0.5、CDR 1和CDR 2的护理者评分分别为2.46 ± 1.85（平均值± SD）、6.36 ± 3.02和9.00 ± 1.14;患者评分分别为2.00 ± 1.78、2.55 ± 2.33和1.33 ± 2.46。差异分别为0.46 ± 1.61、3.81 ± 3.95和7.67 ± 2.87，CDR 1和CDR 2中护理人员评估显著高于患者评估（两组均为p < 0.001）。SED-11 Q用于病感失认症的验证与标准化的痴呆病感失认症问卷（AD-Q）。照顾者评分与痴呆行为和心理症状评分中度相关（r = 0.524），患者评分与抑郁评分中度相关（r = 0.561）。SED-11 Q具有双重目的：护理人员评估可用于筛查痴呆，患者和护理人员评估之间的任何差异均被视为疾病感缺失严重程度的指示;这可以为护理人员提供信息，并对成功护理至关重要。
The objective is to propose a brief method to evaluate anosognosia in Alzheimer's disease (AD) using the Symptoms of Early Dementia-11 Questionnaire (SED-11Q), a short informant-based screening questionnaire for identifying dementia. The participants were 107 elderly individuals: 13 with a Clinical Dementia Rating (CDR) of 0.5, 73 with mild AD of CDR 1, and 21 with moderate AD of CDR 2. The patients and caregivers answered the SED-11Q independently, and the degree of discrepancy indicated the severity of anosognosia. The scores were as follows: caregiver scores were 2.46 ± 1.85 (mean ± SD) in CDR 0.5, 6.36 ± 3.02 in CDR 1, and 9.00 ± 1.14 in CDR 2; patient scores were 2.00 ± 1.78, 2.55 ± 2.33, and 1.33 ± 2.46, respectively. Discrepancy was 0.46 ± 1.61, 3.81 ± 3.95, and 7.67 ± 2.87, respectively, and the caregiver assessments were significantly higher than the patient assessments in CDR 1 and CDR 2 (p < 0.001 in both groups). The SED-11Q for anosognosia was validated with the standardized Anosognosia Questionnaire for Dementia (AD-Q). The caregiver scores were moderately correlated with behavioral and psychological symptoms of dementia scores (r = 0.524), and the patient scores were moderately correlated with depression scores (r = 0.561). The SED-11Q serves a dual purpose: caregiver assessment is useful for the screening of dementia, and any discrepancy between the patient and the caregiver assessment is considered as an indication of the severity of anosognosia; this can be informative for caregivers and essential for successful care.