Children's school performance is not impaired by short-term administration of diphenhydramine or loratadine.
Children's school performance is not impaired by short-term administration of diphenhydramine or loratadine.
复制标题
短期服用苯海拉明或氯雷他定不会损害儿童的学校表现。
DOI：
10.1067/mpd.2001.112647
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Henry Milgrom
中科院分区：
文献类型：
--
作者：
Bruce G. Bender;David R. McCormick;Henry Milgrom
目的
本研究的目的是确定第二代H1抗组胺药是否比经典抗组胺药在儿童中产生更少的镇静作用，并允许在学校环境中进行更多的学习。
研究设计
63名8- 10岁的儿童有季节性过敏性鼻炎病史，但在研究时没有症状，他们被随机分配到3个治疗组中的一个：安慰剂组、苯海拉明组或氯雷他定组。在4个研究日中的3个研究日给予药物，间隔6小时两次，而参与者参加了实验室学校。在每个上学日结束时进行课堂测试，评估儿童对课程材料的记忆情况。通过嗜睡自我报告和计算机化反应时间测试额外评估潜在的镇静作用。
结果
在口头指导评分、阅读测试评分、反应时间或嗜睡量表上未出现给药相关差异。
结论
参加实验室学校的儿童的学习和反应时间没有受到任何抗组胺药的显着影响。
OBJECTIVE
The purpose of this study was to determine whether a second-generation H1 antihistamine produces less sedation in children and permits greater learning in a school setting than a classic antihistamine.
STUDY DESIGN
Sixty-three 8- to 10-year-old children who had histories of seasonal allergic rhinitis but had no symptoms at the time of the study were randomly assigned to 1 of 3 treatment groups: placebo, diphenhydramine, or loratadine. Medications were administered on 3 of 4 study days, twice 6 hours apart, while participants attended a laboratory school. Classroom testing at the end of each school day evaluated the children's retention of curriculum material. Potential sedative effects were additionally evaluated by self-report of somnolence and computerized reaction-time testing.
RESULTS
No treatment-related differences emerged on the verbal instruction score, reading test score, reaction time, or somnolence scale.
CONCLUSIONS
Learning and response time in children attending a laboratory school were not significantly affected by either antihistamine.