Recommendations for neoadjuvant pathologic staging (ypTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals.
Recommendations for neoadjuvant pathologic staging (ypTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals.
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DOI：
10.1111/dote.12538
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Worldwide Esophageal Cancer Collaboration Investigators
中科院分区：
文献类型：
--
作者：
Rice TW;Ishwaran H;Kelsen DP;Hofstetter WL;Apperson-Hansen C;Blackstone EH;Worldwide Esophageal Cancer Collaboration Investigators
我们报告了分析和共识过程，为AJCC/UICC癌症分期手册（第8版）提供了食管和食管胃结合部癌症新辅助病理分期组（ypTNM）的建议。全球食管癌协作组（WECC）提供了22，654例上皮性食管癌患者的数据; 7，773例在新辅助治疗后进行了病理评估。制定了每例患者的风险调整生存率。随机森林分析确定了数据驱动的新辅助病理分期组，其中存活率随着组的增加而单调下降，组间有区别，组内同质。一项额外的分析仅基于ypT、ypN和ypM类别产生了数据驱动的解剖学新辅助病理分期组。AJCC上消化道工作组，通过平滑，简化，扩展和评估临床适用性，产生共识新辅助病理分期组。分级和部位对ypTNM分期的区分力远低于pTNM。没有分级和位置的数据驱动阶段分组产生了鳞状细胞癌和腺癌几乎相同的组。然而，ypTNM组及其相关生存期与pTNM不同。协商一致进程的必要性微乎其微。对于两种细胞类型相同的共有组如下：ypStage I包括ypT 0 - 2N 0 M0; ypStage II ypT 3 N 0 M0; ypStage IIIA ypT 0 - 2N 1 M0; ypStage IIIB ypT 3 N1 M0、ypT 0 - 3 N2和ypT 4aN 0 M0; ypStage IVA ypT 4aN 1 -2、ypT 4 bN 0 -2和ypTanyN 3 M0;和ypStage IVB ypTanyNanyM 1。缺乏等效的病理（pTNM）类别为特有的新辅助病理分类ypTisN 0 - 3 M0和ypT 0 N 0 - 3 M0，不同的阶段组成分，并显着不同的早期和中期生存需要一个统一的，独特的一套阶段分组的患者接受新辅助治疗的细胞类型。
We report analytic and consensus processes that produced recommendations for neoadjuvant pathologic stage groups (ypTNM) of esophageal and esophagogastric junction cancer for AJCC/UICC cancer staging manuals, 8th edition. The Worldwide Esophageal Cancer Collaboration (WECC) provided data for 22,654 patients with epithelial esophageal cancers; 7,773 had pathologic assessment after neoadjuvant therapy. Risk-adjusted survival for each patient was developed. Random Forest analysis identified data-driven neoadjuvant pathologic stage groups wherein survival decreased monotonically with increasing group, was distinctive between groups, and homogeneous within groups. An additional analysis produced data-driven anatomic neoadjuvant pathologic stage groups based only on ypT, ypN, and ypM categories. The AJCC Upper GI Task Force, by smoothing, simplifying, expanding, and assessing clinical applicability, produced consensus neoadjuvant pathologic stage groups. Grade and location were much less discriminating for stage grouping ypTNM than pTNM. Data-driven stage grouping without grade and location produced nearly identical groups for squamous cell carcinoma and adenocarcinoma. However, ypTNM groups and their associated survival differed from pTNM. The need for consensus process was minimal. The consensus groups, identical for both cell types were as follows: ypStage I comprised ypT0-2N0M0; ypStage II ypT3N0M0; ypStage IIIA ypT0-2N1M0; ypStage IIIB ypT3N1M0, ypT0-3N2, and ypT4aN0M0; ypStage IVA ypT4aN1-2, ypT4bN0-2, and ypTanyN3M0; and ypStage IVB ypTanyNanyM1. Absence of equivalent pathologic (pTNM) categories for the peculiar neoadjuvant pathologic categories ypTisN0-3M0 and ypT0N0-3M0, dissimilar stage group compositions, and markedly different early- and intermediate-stage survival necessitated a unified, unique set of stage grouping for patients of either cell type who receive neoadjuvant therapy.
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影响因子：
9
作者：
Schneider, PM;Baldus, SE;Hoelscher, AH
通讯作者：
Hoelscher, AH
影响因子：
5.8
作者：
Stekhoven, Daniel J.;Buehlmann, Peter
通讯作者：
Buehlmann, Peter
DOI：
10.1111/dote.12513
发表时间：
2016-10
期刊：
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
影响因子：
--
作者：
Rice TW;Lerut TE;Orringer MB;Chen LQ;Hofstetter WL;Smithers BM;Rusch VW;van Lanschot J;Chen KN;Davies AR;D'Journo XB;Kesler KA;Luketich JD;Ferguson MK;Räsänen JV;van Hillegersberg R;Fang W;Durand L;Allum WH;Cecconello I;Cerfolio RJ;Pera M;Griffin SM;Burger R;Liu JF;Allen MS;Law S;Watson TJ;Darling GE;Scott WJ;Duranceau A;Denlinger CE;Schipper PH;Ishwaran H;Apperson-Hansen C;DiPaola LM;Semple ME;Blackstone EH
通讯作者：
Blackstone EH
影响因子：
2.6
作者：
Mehta, S. P.;Jose, P.;Grabsch, H. I.
通讯作者：
Grabsch, H. I.
影响因子：
2.1
作者：
Rice, Thomas W.;Blackstone, Eugene H.
通讯作者：
Blackstone, Eugene H.