Room temperature hydroalkylation of electron-deficient olefins:: sp3 C-H functionalization via a Lewis acid-catalyzed intramolecular redox event
Room temperature hydroalkylation of electron-deficient olefins:: sp3 C-H functionalization via a Lewis acid-catalyzed intramolecular redox event
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DOI：
10.1021/ja053337f
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发表时间：
2005-09-07
影响因子：
15
通讯作者：
Sames, D
中科院分区：
文献类型：
--
作者：
Pastine, SJ;McQuaid, KM;Sames, D
A practical method for the intramolecular hydroalkylation of electron-deficient olefins has been developed. The direct transformation of benzylic, tertiary, and sterically hindered secondary sp3C−H bonds into C−C bonds under the action of a catalytic amount of a variety of Lewis acids is described. The mechanism of these transformations is proposed to involve a tandem hydride transfer/cyclization sequence.
