Gene expression profiling of WDR5 regulated genes in bladder cancer
Gene expression profiling of WDR5 regulated genes in bladder cancer
复制标题
膀胱癌中 WDR5 调控基因的基因表达谱
DOI：
10.1016/j.gdata.2015.05.003
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发表时间：
2015-09-01
期刊：
影响因子：
--
通讯作者：
Huang, Jian
中科院分区：
文献类型：
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作者：
Chen, Xu;Gu, Peng;Huang, Jian
WD repeat domain 5 (WDR5) plays an important role in various biological functions through the epigenetic regulation of gene transcription (Wysocka et al., 2005 [1]; Sandstrom et al., 2014[2]; Ang et al., 2011[3]). Recently, our study found thatWDR5 was upregulated in bladder cancer tissues, promoted bladder cancer cell proliferation, self-renewal and chemoresistance to cisplatin in bladder cancer cells in vitro, and tumor growth in vivo (Chen et al., 2015). To gain a molecular understanding of the role of WDR5 in promoting bladder cancer, we performed a genome-wide analysis on WDR5 knockdown by microarray gene expression profiling. Here we provide detailed experimental methods and analysis for the microarray data, which have been deposited into Gene Expression Omnibus (GEO): GSE59132. (C) 2015 The Authors. Published by Elsevier Inc.
