Accumulation of Clostridium perfringens epsilon-toxin in the mouse kidney and its possible biological significance
Accumulation of Clostridium perfringens epsilon-toxin in the mouse kidney and its possible biological significance
复制标题
DOI：
10.1128/iai.71.9.5371-5375.2003
复制
发表时间：
2003-09-01
影响因子：
3.1
通讯作者：
Okabe, A
中科院分区：
文献类型：
--
作者：
Tamai, E;Ishida, T;Okabe, A
在本文中，我们表明，产气荚膜梭菌ε毒素积累主要在小鼠肾脏，在那里它主要分布在肾小球，毛细血管和集合管。虽然在远端小管和集合管中观察到一些致密化和脱落的上皮细胞，但没有发现指示严重肾损伤的结果。双侧肾切除增加毒素的小鼠致死率，表明肾脏有助于宿主防御ε毒素的致死毒性。
In this paper we show that Clostridium perfringens epsilon-toxin accumulates predominantly in the mouse kidney, where it is distributed mainly in glomeruli, capillaries, and collecting ducts. Although some pycnotic and exfoliated epithelial cells were observed in distal tubuli and collecting ducts, there were no findings indicative of severe renal injury. Bilateral nephrectomy increased the mouse lethality of the toxin, suggesting that the kidney contributes to the host defense against the lethal toxicity of epsilon-toxin.