Quantification of Vessel Density in Retinal Optical Coherence Tomography Angiography Images Using Local Fractal Dimension
Quantification of Vessel Density in Retinal Optical Coherence Tomography Angiography Images Using Local Fractal Dimension
复制标题
使用局部分形维数量化视网膜光学相干断层扫描血管造影图像中的血管密度
DOI：
10.1167/iovs.15-18287
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发表时间：
2016-01-01
影响因子：
4.4
通讯作者：
Roy, Abhijit Sinha
中科院分区：
文献类型：
--
作者：
Gadde, Santosh G. K.;Anegondi, Neha;Roy, Abhijit Sinha
目的.评价一种全自动局部分形维数方法在光学相干断层扫描血管造影（OCTA）图像中定量血管密度和中心凹无血管区（FAZ）面积。52例健康的亚洲印度人的眼睛进行了前瞻性成像与OCTA系统。对视网膜浅层和深层血管丛进行成像。局部分形分析应用于OCTA图像。扫描范围为3 ~ 3 ~ 3 mm，分别位于视网膜浅层和深层。在中央凹周围的圆形和扇形区域中量化中央凹无血管区面积和血管密度。开发了一个独特的血管密度和脱落区等高线图，以进行区域比较。分割视网膜浅血管丛（0.35 +/- 0.013 mm（2））和深血管丛（0.49 +/- 0.012 mm（2））的中心凹无血管区。人工分割和局部分形维数分割FAZ面积之间的一致性为0.97（95%置信区间[CI]：0.94-0.98），并没有随着年龄的变化而显着（P = 0.94和0.21，分别）。视网膜血管丛深部的血管密度大于浅层（P < 0.0001）。在FAZ周围分区时，无论是浅层还是深层视网膜血管丛，下分区的血管密度均高于其他分区（颞区、上级和鼻区）（P < 0.05）。这些观察结果与最近动物视网膜血管图的研究结果相似。提出了一种新的局部分形维数计算血管密度和FAZ面积的方法。年龄不影响血管密度，但部门分析显示，更大的血管密度在下区。
PURPOSE. To evaluate a fully automated local fractal dimension method to quantify vessel density and foveal avascular zone (FAZ) area in optical coherence tomography angiography (OCTA) images.METHODS. Fifty-two healthy Asian Indian eyes underwent imaging prospectively with OCTA system. Superficial and deep retinal vascular plexus was imaged. Local fractal analysis was applied to the OCTA images. A scan area of 3 3 3 mm was selected in the superficial and deep retinal layers. Foveal avascular zone area and vessel density were quantified in circular and sectoral zones around the fovea. A unique contour map of vessel density and dropout zones was developed to perform regional comparisons.RESULTS. Foveal avascular zone of superficial (0.35 +/- 0.013 mm(2)) and deep (0.49 +/- 0.012 mm(2)) retinal vascular plexus was segmented. The agreement between the manually segmented and local fractal dimension segmented FAZ area was 0.97 (95% confidence interval [CI]: 0.94-0.98) and did not change significantly with age (P = 0.94 and 0.21, respectively). The vessel density was greater in the deep than the superficial retinal vascular plexus (P < 0.0001). When the image was subdivided into sectors around the FAZ, inferior sector had greater vessel density than the others (temporal, superior, and nasal) in both superficial and deep retinal vascular plexus (P < 0.05). These observations were similar to recent studies on animal retinal vasculature map.CONCLUSIONS. A novel implementation of local fractal dimension to calculate vessel density and FAZ area was demonstrated. Age did not impact vessel density but sectoral analyses showed greater vessel density in the inferior zone.