Adiponectin and inflammatory markers in peripheral arterial occlusive disease
Adiponectin and inflammatory markers in peripheral arterial occlusive disease
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DOI：
10.1016/j.atherosclerosis.2005.10.039
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发表时间：
2006-10-01
期刊：
影响因子：
5.3
通讯作者：
Kawano, Yuhei
中科院分区：
文献类型：
--
作者：
Iwashima, Yoshio;Horio, Takeshi;Kawano, Yuhei
本研究旨在检测外周动脉闭塞性疾病（PAOD）中脂联素的血浆水平以及炎症和内皮功能标志物，并探讨脂联素在该疾病中的病理生理学意义。纳入了 88 名患有 PAOD 的受试者 (n = 40) 和未患有 PAOD 的受试者 (n = 48)。包括年龄、性别、体重指数、高血压、糖尿病、甘油三酯、高密度脂蛋白胆固醇、肌酐、可溶性细胞间粘附分子-1（sICAM-1）、可溶性血管细胞粘附分子-1（sVCAM-1）、冯·维勒布兰德因子和超敏C反应蛋白（Hs-CRP）在内的多元回归分析显示，PAOD受试者的脂联素浓度显着较低（PAOD：7.9+/- 0.7 μg/mL 与无 PAOD 相比：9.5 +/- 0.6 μg/mL，F = 4.94，p < 0.03）。此外，脂联素（F = 8.5，p < 0.01）以及sICAM-1（F = 5.8，p < 0.02）、sVCAM-1（F = 5.9，p < 0.02）和Hs-CRP（F = 3.8，p = 0.05）的浓度与踝肱指数独立相关。在 27 名受试者（10 名患有 PAOD 和 17 名无 PAOD）中，测量了股动脉和隐静脉中的脂联素水平。在没有 PAOD 的受试者中观察到脂联素从动脉到静脉的显着升高（+13.0%，p < 0.01），但在患有 PAOD 的受试者中没有观察到（+0.4%，NS）。对 8 名患者进行经皮腔内血管成形术 (PTA) 前后的血浆脂联素和 Hs-CRP 进行随访。 PTA 后脂联素呈下降趋势（第 6 天，-30.6%），但 Hs-CRP 显着升高。 PAOD 患者的脂联素下降与疾病的严重程度成比例。脂联素浓度可能是动脉粥样硬化存在的标志，测量其浓度可能有助于评估动脉粥样硬化的进展。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
This study was designed to examine the plasma levels of adiponectin as well as markers of inflammation and endothelial function in peripheral arterial occlusive disease (PAOD), and to investigate the pathophysiological significance of adiponectin in this disease. Eighty-eight subjects with (n = 40) and without PAOD (n = 48) were enrolled. Multiple regression analysis including age, sex, body mass index, hypertension, diabetes, triglycerides, high-density lipoprotein cholesterol, creatinine, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cellular adhesion molecules-1 (sVCAM-1), von Willebrand factor, and high-sensitive C reactive protein (Hs-CRP) showed that adiponectin concentration was significantly lower in PAOD subjects (PAOD: 7.9 +/- 0.7 mu g/mL versus without PAOD: 9.5 +/- 0.6 mu g/mL, F = 4.94, p < 0.03). Furthermore, concentrations of adiponectin (F = 8.5, p < 0.01) as well as sICAM-1 (F = 5.8, p < 0.02), sVCAM-1 (F = 5.9, p < 0.02), and Hs-CRP (F = 3.8, p = 0.05) were independently associated with ankle-brachial index. In 27 subjects (10 with PAOD and 17 without PAOD), adiponectin levels in the femoral artery and saphenous vein were measured. A significant step-up of adiponectin from the artery to the vein was observed in subjects without PAOD (+13.0%, p < 0.01), but not in subjects with PAOD (+0.4%, NS). Plasma adiponectin as well as Hs-CRP were followed before and after percutaneous transluminal angioplasty (PTA) in eight patients. Adiponectin showed a tendency to decrease after PTA (day 6, -30.6%), although Hs-CRP significantly increased. Adiponectin is decreased in patients with PAOD in proportion to the severity of the disease. Adiponectin concentration could be a marker of the existence of atherosclerosis, and measurement of its concentration may be helpful in assessment of the progress of atherosclerosis. (c) 2005 Elsevier Ireland Ltd. All rights reserved.