In Vitro and in Vivo Evaluation of the Efficacy of Bovine Colostrum against Human Rotavirus Infection
In Vitro and in Vivo Evaluation of the Efficacy of Bovine Colostrum against Human Rotavirus Infection
复制标题
DOI：
10.1271/bbb.90862
复制
发表时间：
2010-03-01
影响因子：
1.6
通讯作者：
Kanamaru, Yoshihiro
中科院分区：
文献类型：
--
作者：
Inagaki, Mizuho;Yamamoto, Mayumi;Kanamaru, Yoshihiro
从正常奶牛产后6-7 d的牛晚初乳中提取的脱脂浓缩液在体外对人轮状病毒（HRV）有较强的抑制作用。此外，在接种HRV前预防性口服SCBLC一次可预防乳鼠体内腹泻的发生。正常奶牛的SCBLC可能有助于预防免疫功能低下宿主的HRV诱导的严重胃肠炎。
We found that skimmed and concentrated bovine late colostrum (SCBLC) obtained from normal cows at 6-7 d after parturition exhibited high potency in inhibiting replication of human rotavirus (HRV) in vitro. Furthermore, prophylactic oral administration of SCBLC once before inoculation of HRV prevented the development of diarrhea in suckling mice in vivo. SCBLC from normal cows might be useful in the prevention of HRV-induced severe gastroenteritis in immunocompromised hosts.