Effects of an antidepressant on neural correlates of emotional processing in patients with major depression
Effects of an antidepressant on neural correlates of emotional processing in patients with major depression
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DOI：
10.1016/j.neulet.2012.08.034
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发表时间：
2012-10
影响因子：
2.5
通讯作者：
Yan Wang;Cheng Xu;Xiaohua Cao;Qiang Gao;Jianying Li;Zhifen Liu;N. Sun;Yan Ren;Kerang Zhang
中科院分区：
文献类型：
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作者：
Yan Wang;Cheng Xu;Xiaohua Cao;Qiang Gao;Jianying Li;Zhifen Liu;N. Sun;Yan Ren;Kerang Zhang
我们测量了重度抑郁症患者在抗抑郁药物治疗前后观看情绪图片时的大脑活动。参与者包括18名首发未服药的重度抑郁症患者和18名年龄和性别匹配的对照组。所有受试者在基线和氟西汀治疗8周后的功能性磁共振成像扫描期间都执行了一项情绪任务。未服药的抑郁症患者在观察阳性图像时的准确率（0.53±0.26）低于对照组（0.71±0.18）。在暴露于积极刺激时，抗抑郁治疗后患者的右岛叶（BA13）和左前扣带皮层（BA32）的激活减少。在抗抑郁药物治疗后，患者在面对负面刺激时表现出更大的右侧额叶中回（ba8,9）激活。我们的研究结果表明，前额叶皮层、前扣带皮层和脑岛可能作为治疗反应的生物标志物和治疗成功的预测因子发挥关键作用。
We measured brain activation in patients with major depressive disorder when exposed to emotional pictures before and after antidepressant treatment. The participants included 18 first-episode unmedicated patients with current major depressive disorder and 18 age- and gender-matched control subjects. All subjects performed an emotional task during functional magnetic resonance imaging scanning at baseline and after 8 weeks of fluoxetine treatment. Unmedicated depressed patients showed lower accuracy rates (0.53±0.26) than did subjects in the control group (0.71±0.18) while viewing positive pictures. During exposure to positive stimuli, decreased activations were seen in the right insula (BA13) and left anterior cingulate cortex (BA32) in patients after antidepressant treatment. After antidepressant treatment, patients exhibited greater activation in the right middle frontal gyrus (BA8,9) in response to negative stimuli. Our results suggest that the prefrontal cortex, anterior cingulate cortex and insula may play key roles as biological markers for treatment response and as predictors of therapeutic success.