Radiation exposure of patients during 68Ga-DOTATOC PET/CT examinations
Radiation exposure of patients during 68Ga-DOTATOC PET/CT examinations
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DOI：
10.3413/nukmed-0214
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发表时间：
2009-01-01
影响因子：
1.5
通讯作者：
Kotzerke, J.
中科院分区：
文献类型：
--
作者：
Hartmann, H.;Zoephel, K.;Kotzerke, J.
目的：探讨Ga-68-DOTATOC-在诊断或排除神经内分泌肿瘤的临床常规影像学检查中的生物分布及剂量计算。方法：14例患者（8男6女）注射（112 +/- 22）MBq Ga-68-DOTATOC后，在20分钟内进行动态PET/ ct成像（Biograph 16），随后进行全身3d采集（8个床位，每个床位3或4分钟）30分钟和120分钟。测量尿示踪剂的消除，并从心脏的血池中无创地获得血液活性。剂量测定的相关器官为脾脏、肾脏、肝脏、肾上腺、膀胱和脑垂体。使用OLINDA/EXM 1.0软件进行剂量测定，特定器官摄取以标准化摄取值（suv）表示。结果：肝、脾、肾、肾上腺和脑垂体对示踪剂有快速的生理吸收（平均suv分别为6、20、16、10和4）。放射性示踪剂完全通过尿液消除（2h内注射剂量的16%）；没有观察到重新分配。脾脏和肾脏受到的辐射最高（分别为0.24 mSv/MBq、0.22 mSv/MBq），平均有效剂量为0.023 mSv/MBq。结论：Ga-68-DOTATOC与in -111标记的配体相比具有许多优势，可广泛用于生长抑素受体阳性肿瘤的诊断。所得的剂量学值低于octrescan生物数据的初步近似值。使用CT对PET数据进行传输校正可提供高达1毫西弗（低剂量）的辐射暴露。
Aim: Investigation of the biodistribution and calculation of dosimetry of Ga-68-DOTATOC- for patients imaged in the routine clinical setting for diagnosis or exclusion of neuroendocrine tumours. Patients, methods: Dynamic PET/CT-imaging (Biograph 16) was performed over 20 min in 14 patients (8 men, 6 women) after injection of (112 +/- 22) MBq Ga-68-DOTATOC followed by whole body 3D-acquisition (8 bed positions, 3 or 4 min each) 30 min p.i. and 120 min p.i.. Urinary tracer elimination was measured and blood activity was derived non-invasively from the blood pool of the heart. The relevant organs for dosimetry were spleen, kidneys, liver, adrenals, urinary bladder and pituitary gland. Dosimetry was performed using OLINDA/EXM 1.0 software and specific organ uptake was expressed as standardized uptake values (SUVs). Results: Rapid physiological uptake of the radiotracer could be demonstrated in liver, spleen and kidneys, adrenals and pituitary gland (mean SUVs were 6, 20, 16, 10, and 4, respectively). Radiotracer elimination was exclusively via urine (16% of injected dose within 2h); no redistribution could be observed. The spleen and the kidneys received the highest radiation exposure (0.24 mSv/MBq, 0.22 mSv/MBq resp.), mean effective dose yielded 0.023 mSv/MBq. Conclusion: Ga-68-DOTATOC is used extensively for diagnosis of somatostatin receptor positive tumours because it has several advantages over the In-111-labelled ligand. The derived dosimetric values are lower than first approximations from the biological data of OctreoScan. The use of CT for transmission correction of the PET data delivers radiation exposure up to 1 mSv (low dose).