Capillary-tissue arrangement in the skeletal muscle optimized for oxygen transport in all mammals.
Capillary-tissue arrangement in the skeletal muscle optimized for oxygen transport in all mammals.
复制标题
骨骼肌中的毛细血管组织排列针对所有哺乳动物的氧气运输进行了优化。
DOI：
10.1006/mvre.1995.1013
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发表时间：
1995
影响因子：
3.1
通讯作者：
A. Kamiya
中科院分区：
文献类型：
--
作者：
K. Baba;T. Kawamura;M. Shibata;M. Sohirad;A. Kamiya
本计算机模拟研究的目的是评估所有哺乳动物骨骼肌中毛细血管网络向组织输送氧气（O2）的效率。由以下人员执行：（1）毛细血管-组织系统采用Krogh圆柱体模型，血管系统采用最小体积模型，（2）肌肉血流量和耗氧率的异速生长评估（主要输入数据）在休息和运动状态下作为来自几种哺乳动物报告的数据的体重的幂函数，以及（3）根据作为毛细血管数目的函数的比率（组织的最大O2摄取）/（血流供应的最小能量消耗）来计算系统的性价比。体重范围为100 g至1000 kg的结果表明，对于每种体重和代谢状态，效率曲线在特定的最佳毛细血管数处达到峰值，并且总肌肉质量、毛细血管密度、和毛细流动-用最佳毛细血管数和运动时组织半径计算的心率与各种动物的实际测量值吻合得非常好。这些研究结果表明，在所有哺乳动物中，骨骼肌中的毛细血管排列在运动过程中优化O2输送到组织的工作假设的有效性。
The aim of this computer simulation study is to evaluate the efficiency of capillary networks in the skeletal muscle for oxygen (O2) delivery to tissue for all mammals. This was performed by: (1) employing Krogh's cylinder model for the capillary-tissue system and the minimum volume model for the vascular system, (2) allometrically assessing the muscle blood flow and O2 consumption rate (the main input data) in the resting and exercising states as power functions of body weight from the data reported for several mammals, and (3) calculating the cost-performance of the system from the ratio (maximum O2 uptake of tissue)/(minimum energy expenditure of blood flow supply), as a function of number of capillaries. The results obtained for body weights ranging from 100 g to 1000 kg revealed that for each body weight and metabolic state, the efficiency curve attains a peak at a specific optimum capillary number, and that the calculated values of total muscle mass, capillary density, and capillary flow-rate by using the optimum capillary number and tissue radius during exercise agree remarkably well with those actually measured in various animals. These findings suggest the validity of a working hypothesis that in all mammals, the capillary arrangement in the skeletal muscle is optimized for O2 delivery to tissue during exercise.