Mannose binding lectin mediated complement pathway in multiple sclerosis
Mannose binding lectin mediated complement pathway in multiple sclerosis
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DOI：
10.1016/j.jneuroim.2011.08.018
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发表时间：
2011-10-28
影响因子：
3.3
通讯作者：
Singh, Kumud K.
中科院分区：
文献类型：
--
作者：
Kwok, Janet Y.;Vaida, Florin;Singh, Kumud K.
通过检测87例多发性硬化(MS)患者血浆和脑脊液(CSF)中甘露糖结合凝集素(MBL)、甘露糖结合凝集素相关丝氨酸蛋白酶-2(MASP-2)和功能性MBL/MASP-2介导的C4裂解(FMBL)的表达，探讨天然免疫途径--甘露糖结合凝集素(MBL)在多发性硬化(MS)发病机制中的作用。MS患者血浆fMBL和MASP-2水平中位数高于非MS患者。这些关联仍然存在于对MS疾病亚型的分析中。这些发现提示MBL补体途径在MS中可能被激活，这可能改变MS疾病的风险或进展。爱思唯尔出版公司(Elsevier B.V.)
Role of mannose binding lectin (MBL) complement activation pathway, an arm of innate immunity in multiple sclerosis (MS) was evaluated by analyzing the expression of MBL, MBL-associated serine protease-2 (MASP-2), and functional MBL/MASP-2 mediated C4 cleavage (fMBL) in 87 plasma and cerebrospinal fluid (CSF) samples from MS patients and non-MS controls. Median fMBL and MASP-2 plasma levels were higher in MS vs. non-MS cases. These associations remained in an analysis of subtypes of MS disease. These findings suggest a potential activation of MBL complement pathway in MS that may possibly alter the risk or progression of MS disease. Published by Elsevier B.V.