Laminar and synaptic organization of the projection from the thalamic nucleus centralis to primary visual cortex in the cat.
Laminar and synaptic organization of the projection from the thalamic nucleus centralis to primary visual cortex in the cat.
复制标题
猫从丘脑中央核到初级视觉皮层投射的层状和突触组织。
DOI：
10.1002/cne.902540106
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Levay,S
中科院分区：
文献类型：
--
作者：
CunninghamJr,ET;Levay,S
用顺行和逆行追踪技术研究了丘脑板内核（中央核）向初级视皮层的投射。在17和18区大量注射辣根过氧化物酶后，中央核中几乎一半的神经元被逆行标记。将3 H-脯氨酸注射到中央核中，导致在17和18区的第5和6层中出现稀疏的顺行标记。将过氧化物酶结合的麦胚凝集素（WGA）大量注射到中央核中，导致第5层和第6层出现类似的顺行标记，此外，还导致第1层出现一条带。在区域17或18中未观察到逆行标记细胞。在电子显微镜下检查17区的WGA标记终末：它们在树突棘上形成1型（不对称）突触。这些观察结果表明，从中央核的传入主要接触锥体细胞，投射到皮层下的目标。这些发现与生理学研究一致，表明中央核参与了不同唤醒水平的皮质流出的调制。
The projection from the nucleus centralis (an intralaminar thalamic nucleus) to the primary visual cortex was examined with anterograde and retrograde tracing techniques. After large injections of horseradish peroxidase into areas 17 and 18 almost one‐half of the neurons in the nucleus centralis were retrogradely labeled. An injection of3H‐proline into the nucleus centralis led to sparse anterograde labeling in layers 5 and 6 of areas 17 and 18. Large injections of peroxidase‐conjugated wheat germ agglutinin (WGA) into the nucleus centralis led to similar anterograde labeling of layers 5 and 6 and, in addition, to a band in layer 1. No retrogradely labeled cells were seen in areas 17 or 18. The WGA‐labeled terminals in area 17 were examined in the electron microscope: they formed type 1 (asymmetric) synapses on dendritic spines. These observations suggest that the afferents from the nucleus centralis primarily contact pyramidal cells that project to subcortical targets. The findings are consistent with physiological studies suggesting that the nucleus centralis is involved in the modulation of cortical outflow with varying levels of arousal.