Clinicopathologic Features and Predictors for Survival of Mucinous and Nonmucinous Appendiceal Adenocarcinoma
Clinicopathologic Features and Predictors for Survival of Mucinous and Nonmucinous Appendiceal Adenocarcinoma
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DOI：
10.1159/000170880
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发表时间：
2008-01-01
影响因子：
2.7
通讯作者：
Chen, Miin-Fu
中科院分区：
文献类型：
--
作者：
Hsu, Jun-Te;Chen, Han-Ming;Chen, Miin-Fu
背景/目的：我们报道了一项研究，对手术治疗的粘液性和非粘液性阑尾腺癌患者进行了记录检查，以阐明其临床病理特征和生存预后因素。方法：回顾性分析我院1991 ~ 2005年收治的34例黏液性和非黏液性阑尾腺癌的临床资料。结果：黏液性肿瘤与非黏液性肿瘤在患者统计学特征、临床病理特征、手术类型及转归等方面无显著差异。非黏液性肿瘤白细胞增多的发生率高于黏液性肿瘤。34例阑尾腺癌患者5年总生存率为35.8%。在单因素分析中，预测生存的因素是手术类型、可切除性、癌变程度和肿瘤分期。在多变量分析中，肿瘤分期显著影响患者的生存。结论：黏液性阑尾腺癌具有与非黏液性阑尾腺癌相似的临床病理特征和预后，只是非黏液性阑尾腺癌中白细胞增多。肿瘤分期是阑尾腺癌患者生存的独立预测因子。版权所有(c) 2008 S. Karger AG，巴塞尔
Background/Aims: We report a study in patients with mucinous and nonmucinous appendiceal adenocarcinoma treated surgically whose records were examined to elucidate their clinicopathologic features and prognostic factors for survival. Methods: The medical records of 34 patients with mucinous and nonmucinous appendiceal adenocarcinoma (1991-2005) were retrospectively reviewed. Results: There was no significant difference between mucinous and nonmucinous tumors in patient demographics, clinicopathologic features, type of operation and outcome. Nonmucinous tumors had a higher incidence of leukocytosis than mucinous ones. The overall 5-year survival rate for 34 patients with appendiceal adenocarcinoma was 35.8%. In the univariate analysis, predictors of survival were the type of operation, resectability, carcinomatosis and tumor stage. Tumor stage significantly influenced patient survival in the multivariate analysis. Conclusion: Mucinous appendiceal adenocarcinoma had clinicopathologic characteristics and a prognosis similar to nonmucinous, except that there was more leukocytosis in nonmucinous tumors. Tumor stage is an independent predictor for survival among patients with appendiceal adenocarcinoma. Copyright (c) 2008 S. Karger AG, Basel