CONFORMAL ARC RADIOTHERAPY FOR PROSTATE CANCER: INCREASED BIOCHEMICAL FAILURE IN PATIENTS WITH DISTENDED RECTUM ON THE PLANNING COMPUTED TOMOGRAM DESPITE IMAGE GUIDANCE BY IMPLANTED MARKERS
CONFORMAL ARC RADIOTHERAPY FOR PROSTATE CANCER: INCREASED BIOCHEMICAL FAILURE IN PATIENTS WITH DISTENDED RECTUM ON THE PLANNING COMPUTED TOMOGRAM DESPITE IMAGE GUIDANCE BY IMPLANTED MARKERS
复制标题
DOI：
10.1016/j.ijrobp.2008.08.007
复制
发表时间：
2009-06-01
影响因子：
7
通讯作者：
Storme, Guy
中科院分区：
文献类型：
--
作者：
Engels, Benedikt;Soete, Guy;Storme, Guy
目的：探讨直肠扩张对影像引导适形弧线放射治疗前列腺癌患者计划计算机断层扫描生化失败自由度（FFBF）的影响。方法与材料：对238例T1-T3N0M0肿瘤患者的预后进行分析，中位随访53个月（范围24-93个月）。213例患者使用每日x光片和数字重建x线片共同登记进行定位，而25例患者使用植入标记物的直接前列腺可视化进行定位。直肠平均横截面积在计划计算机断层图上确定。结果：根据放射治疗肿瘤组的标准，3 - 4级晚期胃肠道和泌尿系统副作用的5年无发生率分别为100%和99.4%。5年FFBF为88.4%。在多变量分析中，以下变量与FFBF恶化显著相关：根据国家综合癌症网络的风险组（高至极高风险vs中至低风险），剂量（70 Gy vs 78 Gy），平均横截面积(>= 16 vs。
Purpose: To evaluate the effect of rectal distention on the planning computed tomogram on freedom from biochemical failure (FFBF) of prostate cancer patients treated with image-guided conformal arc radiotherapy.Methods and Materials: The outcomes of 238 patients with T1-T3N0M0 tumors were analyzed, with a median follow-up of 53 months (range, 24-93 months). In 213 patients, daily co-registration of X-rays and digitally reconstructed radiographs was used for positioning, whereas in 25 patients positioning was done using direct prostate visualization with implanted markers. The rectal average cross-sectional area was determined on the planning computed tomogram.Results: The 5-year freedom from Grade 3 to 4 late gastrointestinal and urinary side effect, according to the Radiation Therapy Oncology Group criteria, was 100% and 99.4% respectively. The 5-year FFBF was 88.4%. On multivariate analysis the following variables were significantly related to worse FFBF: risk group according to the National Comprehensive Cancer Network (high- to very high risk vs. intermediate- to low-risk), dose (70 vs. 78 Gy), average cross-sectional area (>= 16 vs.