The French glioblastoma biobank (FGB): a national clinicobiological database
The French glioblastoma biobank (FGB): a national clinicobiological database
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DOI：
10.1186/s12967-019-1859-6
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发表时间：
2019-04-23
影响因子：
7.4
通讯作者：
Zemmoura, I.
中科院分区：
文献类型：
--
作者：
Clavreul, Anne;Soulard, Gwenaelle;Zemmoura, I.
胶质母细胞瘤（GB）是最常见和最致命的原发性脑肿瘤。在确定GB的潜在危险因素以及诊断和预后生物标志物方面取得了重大进展。然而，目前新诊断的GB的护理标准，Stupp协议，十多年来一直保持不变。需要基于大型临床生物学数据库的大规模转化项目来提高我们对GB生物学的理解，潜在地促进个性化和特异性靶向治疗的发展。考虑到这一目标，法国已经建立了一个带有良好注释的临床生物学数据库，其中包含来自GB患者的数据和样本：法国GB生物银行（FGB）。方法生物库包含来自法国24个中心的成人GB患者的数据和样本，并提供书面知情同意。临床和生物材料数据以匿名认证的电子病例报告形式存储。生物样本（包括冷冻和福尔马林固定石蜡包埋的肿瘤组织、血液样本和头发）保存在各参与中心的经认证的生物资源中心或肿瘤组织库中。结果共收集1087GB患者的临床资料和生物资料。66%的GB患者有完整的样本（肿瘤、血液、毛发），88%的GB患者至少有一份冷冻肿瘤样本。结论该大型生物库在欧洲是独一无二的，可以支持改善GB护理所需的大规模转化项目。未来还将收集更多的生物材料，如肿瘤周围脑区和粪便样本，以满足研究需求。
BackgroundGlioblastomas (GB) are the most common and lethal primary brain tumors. Significant progress has been made toward identifying potential risk factors for GB and diagnostic and prognostic biomarkers. However, the current standard of care for newly diagnosed GB, the Stupp protocol, has remained unchanged for over a decade. Large-scale translational programs based on a large clinicobiological database are required to improve our understanding of GB biology, potentially facilitating the development of personalized and specifically targeted therapies. With this goal in mind, a well-annotated clinicobiological database housing data and samples from GB patients has been set up in France: the French GB biobank (FGB).MethodsThe biobank contains data and samples from adult GB patients from 24 centers in France providing written informed consent. Clinical and biomaterial data are stored in anonymized certified electronic case report forms. Biological samples (including frozen and formalin-fixed paraffin-embedded tumor tissues, blood samples, and hair) are conserved in certified biological resource centers or tumor tissue banks at each participating center.ResultsClinical data and biological materials have been collected for 1087GB patients. A complete set of samples (tumor, blood and hair) is available for 66%, and at least one frozen tumor sample is available for 88% of the GB patients.ConclusionsThis large biobank is unique in Europe and can support the large-scale translational projects required to improve GB care. Additional biological materials, such as peritumoral brain zone and fecal samples, will be collected in the future, to respond to research needs.