Adiponectin and Intelectin-1: Important Adipokine Players in Obesity-Related Colorectal Carcinogenesis.
Adiponectin and Intelectin-1: Important Adipokine Players in Obesity-Related Colorectal Carcinogenesis.
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DOI：
10.3390/ijms18040866
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发表时间：
2017-04-19
影响因子：
5.6
通讯作者：
Takeuchi T
中科院分区：
文献类型：
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作者：
Kawashima K;Maeda K;Saigo C;Kito Y;Yoshida K;Takeuchi T
超重被认为与结直肠癌风险有关。脂肪组织是由脂肪细胞组成的疏松结缔组织。它现在被认为是一个主要的内分泌器官，分泌体液因子统称为脂肪因子。由调节的脂肪因子及其受体组成的异常激素系统被认为在肥胖条件下的结肠直肠癌发生和癌症进展中起作用。然而，目前还不清楚是否以及如何每个脂肪因子与结直肠癌的发生。值得注意的是，一对最初被认为是肥胖相关脂肪因子的分子在随后的研究中被取消了资格。脂肪因子，脂联素和intelectin-1（也称为omentin-1），其水平在肥胖中降低，在各种癌症中作为肿瘤抑制因子。大量研究表明，脂联素及其受体T-cadherin在结直肠癌发生中的表达和功能不足之间存在联系。此外，我们最近的研究表明，TMEM 207的损失，这是至关重要的在结肠粘膜中的适当加工的intelectin-1，导致intelectin-1的生产不足，从而参与结直肠癌的发生。在这里，我们讨论了最近的理解，脂肪因子在结直肠癌发生中的作用，并随后描述了有效的肿瘤抑制作用的intelectin-1和TMEM 207在结直肠癌。
Overweight is believed to be associated with colorectal cancer risk. Adipose tissue is loose connective tissue composed of adipocytes. It is now recognized as a major endocrine organ, secreting humoral factors collectively called adipokines. Aberrant hormonal systems consisting of modulated adipokines and their receptors are thought to play a role in colorectal carcinogenesis and cancer progression in obese conditions. However, it is still unclear whether and how each adipokine relates to colorectal carcinogenesis. Notably, a couple of molecules that were initially proposed to be obesity-related adipokines were disqualified by subsequent studies. The adipokines, adiponectin, and intelectin-1 (also known as omentin-1), whose levels are decreased in obesity, act as tumor suppressor factors in various cancers. Numerous studies have demonstrated a link between the insufficient expression and function of adiponectin and its receptor, T-cadherin, in colorectal carcinogenesis. Moreover, our recent study indicated that loss of TMEM207, which is critical for the proper processing of intelectin-1 in the colon mucosa, leads to insufficient intelectin-1 production, thus participating in colorectal carcinogenesis. Here, we discuss the recent understanding of the role of adipokines in colorectal carcinogenesis and subsequently describe the potent tumor suppressor roles of intelectin-1 and TMEM207 in colorectal cancer.