Spatiotemporal changes in regularity of gamma oscillations contribute to focal ictogenesis.
Spatiotemporal changes in regularity of gamma oscillations contribute to focal ictogenesis.
复制标题
伽马振荡规则性的时空变化有助于局灶性发作。
DOI：
10.1038/s41598-017-09931-6
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发表时间：
2017-08-24
影响因子：
4.6
通讯作者：
Otsubo H
中科院分区：
文献类型：
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作者：
Sato Y;Wong SM;Iimura Y;Ochi A;Doesburg SM;Otsubo H
在局灶性发作中，脑电图（EEG）记录的伽马振荡（30-70 Hz）与中间神经元的癫痫样同步有关，中间神经元将癫痫发作区（SOZ）与周围的致痫区联系起来。我们假设中间神经元的同步化可以被检测为伽马振荡节律性的规律性的变化。我们使用多尺度熵（MSE）分析，它可以量化EEG节律的规律性，研究伽马振荡的规律性如何在癫痫发作事件的过程中发生变化。我们分析了13例局灶性皮质发育不良患儿的颅内脑电图数据。MSE分析显示MSE评分的以下特征性变化（伽马振荡）：（1）在发作间期，最低MSE评分（2）在发作前期，随着癫痫发作前癫痫发作区MSE评分的增加，癫痫发作前癫痫发作区与致痫区的相似程度增加（在SOZ中γ振荡变得不那么规则）;和（3）在发作期，MSE评分降低（高度规则的γ振荡）在致痫区传播。这些时空变化的规律性的伽玛振荡构成了一个重要的证明，局灶性ictogenesis是由动态变化的interneuron同步。
In focal ictogenesis, gamma oscillations (30–70 Hz) recorded by electroencephalography (EEG) are related to the epileptiform synchronization of interneurons that links the seizure onset zone (SOZ) to the surrounding epileptogenic zone. We hypothesized that the synchronization of interneurons could be detected as changes in the regularity of gamma oscillation rhythmicity. We used multiscale entropy (MSE) analysis, which can quantify the regularity of EEG rhythmicity, to investigate how the regularity of gamma oscillations changes over the course of a seizure event. We analyzed intracranial EEG data from 13 pediatric patients with focal cortical dysplasia. The MSE analysis revealed the following characteristic changes of MSE score (gamma oscillations): (1) during the interictal periods, the lowest MSE score (the most regular gamma oscillations) was always found in the SOZ; (2) during the preictal periods, the SOZ became more similar to the epileptogenic zone as the MSE score increased in the SOZ (gamma oscillations became less regular in the SOZ); and (3) during the ictal periods, a decreasing MSE score (highly regular gamma oscillations) propagated over the epileptogenic zone. These spatiotemporal changes in regularity of gamma oscillations constitute an important demonstration that focal ictogenesis is caused by dynamic changes in interneuron synchronization.