Evidence for pathogenicity of autoreactive T cells in autoimmune bullous diseases shown by animal disease models
Evidence for pathogenicity of autoreactive T cells in autoimmune bullous diseases shown by animal disease models
复制标题
动物疾病模型显示自身反应性 T 细胞在自身免疫性大疱性疾病中致病性的证据
DOI：
10.1111/exd.12011
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发表时间：
2012
影响因子：
3.6
通讯作者：
Shimizu H
中科院分区：
文献类型：
--
作者：
Ujiie H;Shimizu H
自身免疫性大疱性疾病（AIBD）的特征在于皮肤和/或粘膜上的水疱和糜烂，其由针对表皮和表皮基底膜区的结构蛋白的自身抗体引起。这篇观点文章讨论了自身反应性T细胞对大疱性类天疱疮，天疱疮和获得性大疱性表皮病发病机制的贡献，重点是使用这些疾病的活跃动物小鼠模型的研究。既往研究表明，自身反应性T细胞产生的细胞因子、抗原特异性T细胞与B细胞的相互作用以及调节性T细胞的功能可能与AIBD的发病机制有关。在解释实验结果时，应考虑这些动物模型的局限性。进一步了解自身反应性CD 4 +T细胞的致病性可能会导致疾病特异性治疗。
Autoimmune bullous diseases (AIBDs) are characterized by blisters and erosions on the skin and/or mucous membranes, which are caused by autoantibodies directed to structural proteins of the epidermis and the epidermal basement membrane zone. This Viewpoint Essay discusses the contribution by autoreactive T cells to the pathogenesis of bullous pemphigoid, pemphigus and epidermolysis bullosa acquisita, with an emphasis on studies using active animal mouse models for these diseases. Previous studies have demonstrated that cytokines produced by autoreactive T cells, the interaction between antigen‐specific T cells and B cells and the function of regulatory T cells are likely related to the pathogenesis of AIBDs. In interpreting the experimental results, the limitations of those animal models should be considered. Further understanding of the pathogenicity of autoreactive CD4+T cells may lead to disease‐specific treatments.