Swarming of P. aeruginosa: Through the lens of biophysics.
Swarming of P. aeruginosa: Through the lens of biophysics.
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DOI：
10.1063/5.0128140
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发表时间：
2023-09
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集群是细菌在表面上依赖鞭毛的集体运动，在许多细菌物种中都可以观察到。由于这种运动方式的普遍性和多样性，人们提出了多种蜂群模型，但仍缺乏对蜂群一般机制的共识。在这里，我们重点关注铜绿假单胞菌的集群，因为该物种有丰富的实验数据和多种模型，包括植根于生物学和生物物理学的解释。在这篇综述中，我们解决了有关铜绿假单胞菌群体的三个突出问题：是什么驱动了群体的向外扩张，是什么导致了树突模式（卷须）的形成，以及鞭毛的作用是什么？我们回顾了提出生物活性机制的模型，包括表面活性剂传感以及将群体视为薄液膜的基于流体力学的模型。最后，我们将最近对铜绿假单胞菌群的观察与群聚的早期定义进行了协调。该分析表明，与滑动运动相关的机制在铜绿假单胞菌群形成中具有关键作用。
Swarming is a collective flagella-dependent movement of bacteria across a surface that is observed across many species of bacteria. Due to the prevalence and diversity of this motility modality, multiple models of swarming have been proposed, but a consensus on a general mechanism for swarming is still lacking. Here, we focus on swarming by Pseudomonas aeruginosa due to the abundance of experimental data and multiple models for this species, including interpretations that are rooted in biology and biophysics. In this review, we address three outstanding questions about P. aeruginosa swarming: what drives the outward expansion of a swarm, what causes the formation of dendritic patterns (tendrils), and what are the roles of flagella? We review models that propose biologically active mechanisms including surfactant sensing as well as fluid mechanics-based models that consider swarms as thin liquid films. Finally, we reconcile recent observations of P. aeruginosa swarms with early definitions of swarming. This analysis suggests that mechanisms associated with sliding motility have a critical role in P. aeruginosa swarm formation.